CRAT - carnitine O-acetyltransferase Gene

Homo sapiens

Also known as CAT; CAT1; NBIA8

Gene ID: 1384 | Gene type: protein coding

About CRAT

Cytogenetic location: 9q34.11 Genomic coordinates (GRCh38): 9:129,094,794-129,110,793 (from NCBI)

This gene has 22 transcripts (splice variants), 228 orthologues, 6 paralogues and is associated with 1 phenotype. Broad expression in testis (RPKM 76.6), duodenum (RPKM 25.0) and 23 other tissues.

Summary

This gene encodes carnitine O-acetyltransferase, a member of the carnitine Acyltransferase family and a key metabolic pathway Enzyme which plays an important role in energy homeostasis and fat metabolism. This Enzyme catalyzes the reversible transfer of acyl groups from an acyl-CoA thioester to carnitine and regulates the ratio of acyl-CoA/CoA. It is found in both the mitochondria and the peroxisome. Alternative splicing results in transcript variants encoding different isoforms that may localize to different subcellular compartments. [provided by RefSeq, Oct 2016]

CRAT Products(7)

mRNA	Protein	Name
NM_000755.5	NP_000746.3	carnitine O-acetyltransferase isoform 1
NM_001257363.3	NP_001244292.2	carnitine O-acetyltransferase isoform 2
NM_001346546.2	NP_001333475.2	carnitine O-acetyltransferase isoform 3
NM_001346547.2	NP_001333476.2	carnitine O-acetyltransferase isoform 4
NM_001346548.2	NP_001333477.2	carnitine O-acetyltransferase isoform 5
NM_001346549.2	NP_001333478.2	carnitine O-acetyltransferase isoform 6
NM_004003.4	NP_003994.3	carnitine O-acetyltransferase isoform 2

CRAT Protein Structure

Carn_acyltransf

0
100
200
300
400
500
626 a.a.

Protein Preferred Names

Protein Names

carnitine O-acetyltransferase

carnitine acetylase

Related Diseases

Diseases

Alias

Neurodegeneration With Brain Iron Accumulation 8

NBIA8

Neurodegeneration With Brain Iron Accumulation

Nbia	Neurodegeneration With Brain Iron Accumulation Disorders
Neurodegeneration, With Brain Iron Accumulation

Carnitine Acetyltransferase Deficiency

Acetyl-Carnitine Deficiency

Deficiency Of Carnitine Acetyltransferase

Overnutrition

Basal Ganglia Disease

Basal Ganglia Diseases	Basal Ganglia Disorders
Abnormality Of The Basal Ganglia

Apical Myocardial Infarction

Carnitine Palmitoyltransferase I Deficiency

Carnitine Palmitoyl Transferase 1a Deficiency	Cpt1a Deficiency
Cpt I Deficiency	Carnitine Palmitoyl Transferase Ia Deficiency
Hepatic Carnitine Palmitoyl Transferase 1 Deficiency	Hepatic Carnitine Palmitoyl Transferase I Deficiency
L-Cpt1 Deficiency	Carnitine Palmitoyltransferase 1a Deficiency
Carnitine Palmitoyltransferase Ia Deficiency	Cpt Deficiency, Hepatic, Type I
Cpt Deficiency, Hepatic, Type Ia	Hepatic Carnitine Palmitoyltransferase 1 Deficiency
L-Cpti Deficiency	Hepatic Cpt Deficiency Type I
Hepatic Cpt1	L-Cpt 1 Deficiency
Cpt 1a Deficiency	Liver Form Of Carnitine Palmitoyltransferase Deficiency
CPT1AD	Cpt-I Deficiency

Narcolepsy

Paroxysmal Sleep	Gelineau Syndrome
Narcoleptic Syndrome	Narcolepsy-Cataplexy Syndrome
Cataplexy And Narcolepsy	Narcolepsy, Without Cataplexy
Gelineau'S Syndrome	Narcolepsy With Or Without Cataplexy
Narcolepsy Nos

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency
Primary Immunodeficiency Disease	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

Myopathy

Muscular Diseases

Myopathies

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03139	CRAT Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CRAT	VGNC	VGNC:71483
Rattus norvegicus	CRAT	RGD	RGD:1303031
Felis catus	CRAT	VGNC	VGNC:61159
Mus musculus	CRAT	MGD	MGI:109501
Bos taurus	CRAT	VGNC	VGNC:27687
Canis familiaris	CRAT	VGNC	VGNC:39592