Eps15 - epidermal growth factor receptor pathway substrate 15 Gene

Also Known as 2410112D09Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13858

Summary

Enables identical protein binding activity. Acts upstream of or within regulation of protein localization. Located in ciliary membrane; clathrin-coated pit; and clathrin-coated vesicle. Part of AP-2 adaptor complex. Is expressed in several structures, including adrenal gland; alimentary system; heart; metanephros; and nervous system. Orthologous to human EPS15 (epidermal growth factor receptor pathway substrate 15). [provided by Alliance of Genome Resources, Apr 2022]

Eps15 Products (2)

mRNA Protein Name
NM_001159964.1 NP_001153436.1 epidermal growth factor receptor substrate 15 isoform B
NM_007943.3 NP_031969.1 epidermal growth factor receptor substrate 15 isoform A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
18154663 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9446614 MGI
enables ubiquitin binding IDA
IDA: Inferred from direct assay
15383614 MGI
enables ubiquitin binding IMP
IMP: Inferred from mutant phenotype
15383614 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within regulation of protein localization IMP
IMP: Inferred from mutant phenotype
17868307 MGI
involved in ubiquitin-dependent endocytosis IMP
IMP: Inferred from mutant phenotype
15383614 MGI
Cellular Component GO Annotation Evidence References Source
part of AP-2 adaptor complex IDA
IDA: Inferred from direct assay
17626015 MGI
located in ciliary membrane IDA
IDA: Inferred from direct assay
20427320 MGI
part of clathrin coat of coated pit IDA
IDA: Inferred from direct assay
18434600 MGI
located in clathrin-coated pit IDA
IDA: Inferred from direct assay
20427320 MGI
located in clathrin-coated vesicle IDA
IDA: Inferred from direct assay
17626015 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
17626015 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

epidermal growth factor receptor substrate 15

  • epidermal growth factor pathway substrate 15

  • protein AF-1p

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04452 EPS15 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04453 EPS15L1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22489 Eps15 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29012 Eps15 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Eps15 NCBI NCBI:2060