Esr2 - estrogen receptor 2 (beta) Gene

Also Known as ER[b]; Estrb; ERbeta

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13983

About Esr2

Chromosome 12: 76,167,193-76,224,033 reverse strand.GRCm39:CM001005.3

This gene has 5 transcripts (splice variants), 277 orthologues, 8 paralogues and is associated with 141 phenotypes.

Summary

Enables DNA binding activity. Acts upstream of or within several processes, including hormone-mediated signaling pathway; nervous system development; and reproductive structure development. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; genitourinary system; heart mesentery; limb segment; and mammary gland primordium. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); hypospadias; neurodegenerative disease (multiple); and ovarian dysgenesis 8. Orthologous to human ESR2 (Estrogen receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Esr2 Products (2)

mRNA Protein Name
NM_207707.1 NP_997590.1 estrogen receptor beta isoform 1
NM_010157.3 NP_034287.3 estrogen receptor beta isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
9058381 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11704680 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of androgen receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
12370428 MGI
acts upstream of or within brain development IMP
IMP: Inferred from mutant phenotype
12515851 MGI
acts upstream of cell population proliferation IGI
IGI: Inferred from genetic interaction
18464259 MGI
acts upstream of or within epithelial cell maturation involved in prostate gland development IMP
IMP: Inferred from mutant phenotype
15187231 MGI
acts upstream of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
12370428 MGI
acts upstream of or within estrogen receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
12370428 MGI
acts upstream of or within hormone-mediated apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
15187231 MGI
acts upstream of or within negative regulation of androgen receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
12370428 MGI
acts upstream of or within negative regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
18464259 MGI
acts upstream of or within negative regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
12370428 MGI
acts upstream of or within neuron migration IMP
IMP: Inferred from mutant phenotype
12515851 MGI
acts upstream of or within ovarian follicle development IMP
IMP: Inferred from mutant phenotype
9861029 MGI
acts upstream of or within prostate gland epithelium morphogenesis IMP
IMP: Inferred from mutant phenotype
12370428 MGI
acts upstream of or within regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
9697695 MGI
acts upstream of or within uterus development IGI
IGI: Inferred from genetic interaction
10976058 MGI
acts upstream of or within vagina development IGI
IGI: Inferred from genetic interaction
10976058 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
14552897 MGI
located in nucleus IDA
IDA: Inferred from direct assay
12801993 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

estrogen receptor beta

  • ER-beta

  • nuclear receptor subfamily 3 group A member 2

  • oestrogen receptor beta

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-169063 ZINC05925939 Inhibitor / Unkown
HY-RS04532 ESR2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04533 Esr2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04534 Esr2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Esr2 NCBI NCBI:2100