2. Gene
  3. MUC17 - mucin 17, cell surface associated Gene

MUC17 - mucin 17, cell surface associated Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MUC3; MUC-3; MUC-17

Gene ID: 140453 | Gene type: protein coding

About MUC17

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:101,020,081-101,058,859 (from NCBI)

This gene has 4 transcripts (splice variants), 46 orthologues and 2 paralogues. Biased expression in small intestine (RPKM 22.6), duodenum (RPKM 12.5) and 1 other tissue.

Summary

The protein encoded by this gene is a membrane-bound Mucin that provides protection to gut epithelial cells. The encoded protein contains about 60 tandem repeats, with each repeat being around 60 aa. N-glycosylation enables the encoded protein to localize on the cell surface, while the C-terminus interacts with the scaffold protein PDZ domain containing 1 (PDZK1). Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Nov 2015]

MUC17 Products(1)

mRNA Protein Name
NM_001040105.2 NP_001035194.1 mucin-17 precursor

MUC17 Protein Structure

SEA

SEA: SEA domain (4187 - 4282)

  • 0
  • 700
  • 1400
  • 2100
  • 2800
  • 3500
  • 4200
  • 4493 a.a.
Protein Preferred Names Protein Names

mucin-17

membrane mucin MUC17

Recombinant MUC17 Proteins

Cat. No. Product Name Accession Purity
HY-P78744 MUC-17 Protein, Human (HEK293, His) Q685J3-1 (R4131-L4390) ≥95%

Related Diseases

Diseases Alias
Adenocarcinoma

Adenocarcinomas

Adenoacanthoma Of Unspecified Site

Adenocarcinoid Of Unspecified Site

Adenocarcinoid Tumour Of Unspecified Site

Adenocarcinoma And Carcinoid Combined Of Unspecified Site

Adenocarcinoma Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99523 Vepsitamab 98.44% Phase 1
Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08836 MUC17 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus MUC17 MGD MGI:1203527
Rattus norvegicus MUC17 RGD RGD:3124