MUC17 - mucin 17, cell surface associated Gene

Also Known as MUC3; MUC-3; MUC-17

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 140453

About MUC17

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:101,020,081-101,058,859 (from NCBI)

This gene has 4 transcripts (splice variants), 46 orthologues and 2 paralogues. Biased expression in small intestine (RPKM 22.6), duodenum (RPKM 12.5) and 1 other tissue.

Summary

The protein encoded by this gene is a membrane-bound Mucin that provides protection to gut epithelial cells. The encoded protein contains about 60 tandem repeats, with each repeat being around 60 aa. N-glycosylation enables the encoded protein to localize on the cell surface, while the C-terminus interacts with the scaffold protein PDZ domain containing 1 (PDZK1). Two transcript variants, one protein-coding and the Other non-protein coding, have been found for this gene. [provided by RefSeq, Nov 2015]

MUC17 Products (1)

mRNA Protein Name
NM_001040105.2 NP_001035194.1 mucin-17 precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables PDZ domain binding IPI
IPI: Inferred from physical interaction
17990980 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17990980 GOA
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
17990980 GOA
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
12888891 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MUC17 Protein Structure

SEA

SEA: SEA domain (4187 - 4282)

  • 0
  • 700
  • 1400
  • 2100
  • 2800
  • 3500
  • 4200
  • 4493 a.a.
Protein Preferred Names Protein Names

mucin-17

  • membrane mucin MUC17

Recombinant MUC17 Proteins

Cat. No. Product Name Accession Purity
HY-P78744 MUC-17 Protein, Human (HEK293, His) Q685J3-1 (R4131-L4390) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Adenocarcinoma

  • Adenocarcinomas

  • Adenoacanthoma Of Unspecified Site

  • Adenocarcinoid Of Unspecified Site

  • Adenocarcinoid Tumour Of Unspecified Site

  • Adenocarcinoma And Carcinoid Combined Of Unspecified Site

  • Adenocarcinoma Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99523 Vepsitamab 98.44% Phase 1

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08836 MUC17 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18669 Muc17 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25155 Muc17 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991102 Anti-MUC17 Antibody Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus MUC17 MGD MGI:1203527
Rattus norvegicus MUC17 RGD RGD:3124