Chek1 - checkpoint kinase 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 140583

About Chek1

Primary_assembly 8: 36,420,569-36,441,009 reverse strand.mRatBN7.2:CM026981.1

This gene has 3 transcripts (splice variants), 178 orthologues and is associated with 11 phenotypes. Biased expression in Thymus (RPKM 6.4), Spleen (RPKM 33.5) and 9 other tissues.

Summary

Enables protein kinase activity. Involved in several processes, including DNA damage induced protein phosphorylation; cellular response to caffeine; and negative regulation of G2/M transition of mitotic cell cycle. Predicted to be located in several cellular components, including centrosome; chromosome; and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Predicted to colocalize with chromosome, telomeric region. Human ortholog(s) of this gene implicated in pancreatic Cancer. Orthologous to human CHEK1 (checkpoint kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Chek1 Products (2)

mRNA Protein Name
NM_080400.2 NP_536325.1 serine/threonine-protein kinase Chk1
NM_080400.2 NP_536325.1 serine/threonine-protein kinase Chk1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11687578 RGD
enables protein kinase activity IDA
IDA: Inferred from direct assay
11278490 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to caffeine IEP
IEP: Inferred from expression pattern
11278490 RGD
involved in negative regulation of DNA biosynthetic process IMP
IMP: Inferred from mutant phenotype
12429946 RGD
involved in negative regulation of G2/M transition of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
11278490 RGD
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
11278490 RGD
involved in signal transduction in response to DNA damage IMP
IMP: Inferred from mutant phenotype
11278490 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Chek1 Protein Structure

STKc_Chk1

STKc_Chk1: cd14069 (6 - 264)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 476 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase Chk1

  • CHK1 checkpoint homolog

  • checkpoint kinase 1 homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-148065 FMF-06-098-1 Inhibitor 98.77% Unkown
HY-RS02616 CHEK1 Human Pre-designed siRNA Set A / Unkown
HY-173147 CDK2-IN-42 Inhibitor / Unkown
HY-N15249 4"-Isovalerylspiramycin I / Unkown
HY-RS02617 Chek1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS02618 Chek1 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Chek1 NCBI NCBI:1111