STK35 - serine/threonine kinase 35 Gene

Also Known as CLIK1; STK35L1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 140901

About STK35

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:2,101,827-2,148,555 (from NCBI)

This gene has 2 transcripts (splice variants), 261 orthologues and 8 paralogues. Ubiquitous expression in testis (RPKM 8.0), esophagus (RPKM 4.7) and 25 other tissues.

Summary

The protein encoded by this gene is a kinase that is predominantly found in the nucleus. However, it can interact with PDLIM1/CLP-36 in the cytoplasm and localize to actin stress fibers. The encoded protein may be a regulator of actin stress fibers in nonmuscle cells. [provided by RefSeq, Jul 2008]

STK35 Products (1)

mRNA Protein Name
NM_080836.4 NP_543026.2 serine/threonine-protein kinase 35

STK35 Protein Structure

Pkinase

Pkinase: Protein kinase domain (202 - 523)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 534 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase 35

  • CLIK-1

STK35 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
STK35 Q8TDR2 OSBPL3 Homo sapiens Q9H4L5
Y2H Array
32296183
Intra
STK35 Q8TDR2 OSBPL3 Homo sapiens Q9H4L5
Y2H Prey Pooling
32296183
Intra
STK35 Q8TDR2 OSBPL3 Homo sapiens Q9H4L5
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-148065 FMF-06-098-1 Inhibitor 98.77% Unkown
HY-148061 DB1113 99.86% Unkown
HY-148062 RSS0680 Degrader 99.85% Unkown
HY-148063 DB0614 99.92% Unkown
HY-137340 WH-10417-099 Degrader 98.14% Unkown
HY-RS13936 STK35 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22836 Stk35 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29351 Stk35 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus STK35 VGNC VGNC:65784
Macaca mulatta STK35 VGNC VGNC:78134
Bos taurus STK35 VGNC VGNC:35397
Rattus norvegicus STK35 RGD RGD:1310247
Canis familiaris STK35 VGNC VGNC:46917
Mus musculus STK35 MGD MGI:1914583
Others STK35 NCBI