Fgf10 - fibroblast growth factor 10 Gene

Also Known as AEY17; Fgf5a; Fgf-10; Gsfaey17

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14165

Summary

Enables chemoattractant activity. Involved in positive regulation of transcription, DNA-templated and radial glial cell differentiation. Acts upstream of or within several processes, including animal organ development; positive regulation of cell population proliferation; and regulation of signal transduction. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Used to study LADD syndrome and intestinal atresia. Human ortholog(s) of this gene implicated in LADD syndrome and aplasia of lacrimal and salivary glands. Orthologous to human FGF10 (Fibroblast Growth Factor 10). [provided by Alliance of Genome Resources, Apr 2022]

Fgf10 Products (1)

mRNA Protein Name
NM_008002.5 NP_032028.1 fibroblast growth factor 10 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chemoattractant activity IDA
IDA: Inferred from direct assay
15531758 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15806171 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of ERK1 and ERK2 cascade IGI
IGI: Inferred from genetic interaction
17202188 MGI
acts upstream of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
15130516 MGI
acts upstream of or within Harderian gland development IMP
IMP: Inferred from mutant phenotype
10964474 MGI
acts upstream of Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
17560563 MGI
acts upstream of or within animal organ formation IMP
IMP: Inferred from mutant phenotype
11062007 MGI
acts upstream of or within animal organ morphogenesis IDA
IDA: Inferred from direct assay
14651921 MGI
acts upstream of or within animal organ morphogenesis IMP
IMP: Inferred from mutant phenotype
10964474 MGI
acts upstream of or within blood vessel morphogenesis IMP
IMP: Inferred from mutant phenotype
17560563 MGI
acts upstream of or within blood vessel remodeling IGI
IGI: Inferred from genetic interaction
17000704 MGI
acts upstream of or within branch elongation involved in salivary gland morphogenesis IMP
IMP: Inferred from mutant phenotype
15972105 MGI
acts upstream of or within branching involved in salivary gland morphogenesis IDA
IDA: Inferred from direct assay
18559345 MGI
acts upstream of or within branching involved in salivary gland morphogenesis IGI
IGI: Inferred from genetic interaction
15972105 MGI
acts upstream of or within bronchiole morphogenesis IMP
IMP: Inferred from mutant phenotype
15800000 MGI
acts upstream of or within bud elongation involved in lung branching IGI
IGI: Inferred from genetic interaction
21764747 MGI
acts upstream of cell population proliferation IDA
IDA: Inferred from direct assay
9428423 MGI
acts upstream of or within cell-cell signaling IDA
IDA: Inferred from direct assay
9428423 MGI
acts upstream of or within cell-cell signaling IMP
IMP: Inferred from mutant phenotype
15199404 MGI
acts upstream of or within chemotaxis IDA
IDA: Inferred from direct assay
16169547 MGI
acts upstream of or within determination of left/right symmetry IMP
IMP: Inferred from mutant phenotype
15329346 MGI
acts upstream of or within digestive tract development IMP
IMP: Inferred from mutant phenotype
15234214 MGI
acts upstream of or within embryonic camera-type eye development IMP
IMP: Inferred from mutant phenotype
15958512 MGI
acts upstream of or within embryonic digestive tract development IMP
IMP: Inferred from mutant phenotype
16308329 MGI
acts upstream of or within embryonic digestive tract morphogenesis IMP
IMP: Inferred from mutant phenotype
15017552 MGI
acts upstream of or within embryonic genitalia morphogenesis IMP
IMP: Inferred from mutant phenotype
12004962 MGI
acts upstream of or within embryonic pattern specification IMP
IMP: Inferred from mutant phenotype
16618415 MGI
acts upstream of endothelial cell proliferation IDA
IDA: Inferred from direct assay
14697353 MGI
acts upstream of or within epidermis development IMP
IMP: Inferred from mutant phenotype
10984614 MGI
acts upstream of or within epidermis morphogenesis IMP
IMP: Inferred from mutant phenotype
14530295 MGI
acts upstream of epithelial cell differentiation IDA
IDA: Inferred from direct assay
14604677 MGI
acts upstream of or within epithelial cell differentiation IMP
IMP: Inferred from mutant phenotype
16618415 MGI
acts upstream of epithelial cell proliferation IDA
IDA: Inferred from direct assay
9428423 MGI
acts upstream of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
15972105 MGI
acts upstream of or within epithelial cell proliferation involved in salivary gland morphogenesis IGI
IGI: Inferred from genetic interaction
15972105 MGI
acts upstream of or within epithelial cell proliferation involved in salivary gland morphogenesis IMP
IMP: Inferred from mutant phenotype
15972105 MGI
acts upstream of or within epithelial tube branching involved in lung morphogenesis IDA
IDA: Inferred from direct assay
9428423 MGI
acts upstream of or within epithelial tube branching involved in lung morphogenesis IMP
IMP: Inferred from mutant phenotype
9784490 MGI
acts upstream of or within establishment of mitotic spindle orientation IGI
IGI: Inferred from genetic interaction
21764747 MGI
acts upstream of extrinsic apoptotic signaling pathway in absence of ligand IMP
IMP: Inferred from mutant phenotype
16956603 MGI
acts upstream of or within female genitalia morphogenesis IMP
IMP: Inferred from mutant phenotype
12004962 MGI
acts upstream of or within fibroblast growth factor receptor apoptotic signaling pathway IDA
IDA: Inferred from direct assay
16720875 MGI
acts upstream of or within fibroblast growth factor receptor apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
16720875 MGI
acts upstream of or within fibroblast growth factor receptor signaling pathway involved in mammary gland specification IDA
IDA: Inferred from direct assay
16720875 MGI
acts upstream of or within fibroblast growth factor receptor signaling pathway involved in mammary gland specification IMP
IMP: Inferred from mutant phenotype
16720875 MGI
acts upstream of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
15130516 MGI
acts upstream of or within hair follicle morphogenesis IMP
IMP: Inferred from mutant phenotype
11062007 MGI
acts upstream of or within induction of positive chemotaxis IDA
IDA: Inferred from direct assay
16308329 MGI
acts upstream of or within inner ear morphogenesis IGI
IGI: Inferred from genetic interaction
16691564 MGI
acts upstream of or within inner ear morphogenesis IMP
IMP: Inferred from mutant phenotype
11062007 MGI
acts upstream of keratinocyte proliferation IMP
IMP: Inferred from mutant phenotype
10984614 MGI
acts upstream of or within lacrimal gland development IMP
IMP: Inferred from mutant phenotype
10821755 MGI
acts upstream of or within limb bud formation IMP
IMP: Inferred from mutant phenotype
9784490 MGI
acts upstream of or within limb development IMP
IMP: Inferred from mutant phenotype
10804187 MGI
acts upstream of or within limb morphogenesis IMP
IMP: Inferred from mutant phenotype
9916808 MGI
acts upstream of or within lung alveolus development IGI
IGI: Inferred from genetic interaction
16989802 MGI
acts upstream of or within lung alveolus development IMP
IMP: Inferred from mutant phenotype
17560563 MGI
acts upstream of or within lung development IDA
IDA: Inferred from direct assay
9428423 MGI
acts upstream of or within lung development IMP
IMP: Inferred from mutant phenotype
9916808 MGI
acts upstream of or within lung morphogenesis IMP
IMP: Inferred from mutant phenotype
15800000 MGI
acts upstream of or within lung proximal/distal axis specification IDA
IDA: Inferred from direct assay
15531758 MGI
acts upstream of or within male genitalia morphogenesis IMP
IMP: Inferred from mutant phenotype
12004962 MGI
acts upstream of or within mammary gland bud formation IMP
IMP: Inferred from mutant phenotype
11782400 MGI
acts upstream of or within mammary gland specification IGI
IGI: Inferred from genetic interaction
16720875 MGI
acts upstream of or within mesenchymal cell differentiation involved in lung development IGI
IGI: Inferred from genetic interaction
16989802 MGI
acts upstream of or within mesenchymal-epithelial cell signaling involved in lung development IDA
IDA: Inferred from direct assay
15531758 MGI
acts upstream of or within metanephros morphogenesis IMP
IMP: Inferred from mutant phenotype
11062007 MGI
acts upstream of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
16956603 MGI
acts upstream of or within muscle cell fate commitment IMP
IMP: Inferred from mutant phenotype
15800000 MGI
acts upstream of or within negative regulation of epithelial cell differentiation IDA
IDA: Inferred from direct assay
14604677 MGI
acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IMP
IMP: Inferred from mutant phenotype
16956603 MGI
acts upstream of or within negative regulation of stem cell proliferation IDA
IDA: Inferred from direct assay
16141225 MGI
acts upstream of or within odontogenesis of dentin-containing tooth IMP
IMP: Inferred from mutant phenotype
11062007 MGI
acts upstream of or within organ growth IMP
IMP: Inferred from mutant phenotype
16618415 MGI
acts upstream of or within organ induction IGI
IGI: Inferred from genetic interaction
12810586 MGI
acts upstream of or within otic vesicle formation IGI
IGI: Inferred from genetic interaction
14623822 MGI
acts upstream of or within pancreas development IMP
IMP: Inferred from mutant phenotype
15329346 MGI
acts upstream of or within pituitary gland development IMP
IMP: Inferred from mutant phenotype
11062007 MGI
acts upstream of or within positive chemotaxis IDA
IDA: Inferred from direct assay
15531758 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
17394208 MGI
acts upstream of or within positive regulation of ERK1 and ERK2 cascade IGI
IGI: Inferred from genetic interaction
17202188 MGI
acts upstream of or within positive regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
15130516 MGI
acts upstream of or within positive regulation of Notch signaling pathway IGI
IGI: Inferred from genetic interaction
16324690 MGI
acts upstream of or within positive regulation of Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
17560563 MGI
acts upstream of or within positive regulation of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
16720875 MGI
acts upstream of or within positive regulation of endothelial cell proliferation IDA
IDA: Inferred from direct assay
14697353 MGI
acts upstream of or within positive regulation of epithelial cell migration IDA
IDA: Inferred from direct assay
15531758 MGI
acts upstream of or within positive regulation of epithelial cell migration IMP
IMP: Inferred from mutant phenotype
15958512 MGI
acts upstream of or within positive regulation of epithelial cell proliferation IDA
IDA: Inferred from direct assay
9428423 MGI
acts upstream of or within positive regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
15958512 MGI
acts upstream of or within positive regulation of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
15130516 MGI
acts upstream of or within positive regulation of keratinocyte proliferation IMP
IMP: Inferred from mutant phenotype
10984614 MGI
acts upstream of or within positive regulation of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
16956603 MGI
acts upstream of or within positive regulation of stem cell proliferation IDA
IDA: Inferred from direct assay
15199404 MGI
acts upstream of or within positive regulation of stem cell proliferation IMP
IMP: Inferred from mutant phenotype
10984614 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
11287183 MGI
acts upstream of or within positive regulation of vascular endothelial growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
17560563 MGI
acts upstream of or within positive regulation of white fat cell proliferation IMP
IMP: Inferred from mutant phenotype
15130516 MGI
acts upstream of or within prostatic bud formation IGI
IGI: Inferred from genetic interaction
12941620 MGI
involved in radial glial cell differentiation IMP
IMP: Inferred from mutant phenotype
19607792 MGI
acts upstream of or within regulation of activin receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
15958512 MGI
acts upstream of or within regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling IDA
IDA: Inferred from direct assay
18559345 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
15958512 MGI
acts upstream of or within regulation of smoothened signaling pathway IMP
IMP: Inferred from mutant phenotype
15958512 MGI
acts upstream of or within respiratory system development IDA
IDA: Inferred from direct assay
11287183 MGI
acts upstream of or within salivary gland morphogenesis IMP
IMP: Inferred from mutant phenotype
15654336 MGI
acts upstream of or within semicircular canal fusion IMP
IMP: Inferred from mutant phenotype
15765517 MGI
acts upstream of or within semicircular canal morphogenesis IGI
IGI: Inferred from genetic interaction
17601531 MGI
acts upstream of or within smooth muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
17560563 MGI
acts upstream of or within somatic stem cell population maintenance IMP
IMP: Inferred from mutant phenotype
11880361 MGI
acts upstream of or within spleen development IMP
IMP: Inferred from mutant phenotype
15329346 MGI
acts upstream of stem cell proliferation IDA
IDA: Inferred from direct assay
15199404 MGI
acts upstream of stem cell proliferation IMP
IMP: Inferred from mutant phenotype
10984614 MGI
acts upstream of or within submandibular salivary gland formation IMP
IMP: Inferred from mutant phenotype
11062007 MGI
acts upstream of or within thyroid gland development IMP
IMP: Inferred from mutant phenotype
11062007 MGI
acts upstream of or within type II pneumocyte differentiation IDA
IDA: Inferred from direct assay
15531758 MGI
acts upstream of vascular endothelial growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
17560563 MGI
acts upstream of or within white fat cell differentiation IMP
IMP: Inferred from mutant phenotype
11959839 MGI
acts upstream of white fat cell proliferation IMP
IMP: Inferred from mutant phenotype
15130516 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
9393979 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

fibroblast growth factor 10

  • fibroblast growth factor 5a

  • keratinocyte growth factor 2

Recombinant Fgf10 Proteins

Cat. No. Product Name Accession Purity
HY-P7170 KGF-2/FGF-10 Protein, Mouse O35565 (S62-T209) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04887 FGF10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174711 Human FGF10 mRNA / Unkown
HY-RS16590 Fgf10 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23025 Fgf10 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991584 HuGAL-FR21 Inhibitor 97.80% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fgf10 NCBI NCBI:2255