Fgf8 - fibroblast growth factor 8 Gene

Also Known as Aigf; Fgf-8; Fgf6c; HBGF-8

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14179

Summary

Predicted to enable signaling receptor binding activity. Involved in outflow tract septum morphogenesis. Acts upstream of or within several processes, including animal organ development; blood vessel morphogenesis; and embryonic morphogenesis. Predicted to be located in external side of plasma membrane. Predicted to be active in cytoplasm and extracellular space. Is expressed in several structures, including alimentary system; branchial arch; embryo ectoderm; embryo mesenchyme; and sensory organ. Used to study DiGeorge syndrome and tetralogy of Fallot. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 6 with or without anosmia and prostate carcinoma in situ. Orthologous to human FGF8 (Fibroblast Growth Factor 8). [provided by Alliance of Genome Resources, Apr 2022]

Fgf8 Products (7)

mRNA Protein Name
NM_001166361.2 NP_001159833.1 fibroblast growth factor 8 isoform 2 precursor
NM_001166362.2 NP_001159834.1 fibroblast growth factor 8 isoform 3 precursor
NM_001166363.2 NP_001159835.1 fibroblast growth factor 8 isoform 4 precursor
NM_001379139.1 NP_001366068.1 fibroblast growth factor 8 isoform 5 precursor
NM_001379140.1 NP_001366069.1 fibroblast growth factor 8 isoform 6 precursor
NM_001403100.1 NP_001390029.1 fibroblast growth factor 8 isoform 7 precursor
NM_010205.3 NP_034335.1 fibroblast growth factor 8 isoform 1 precursor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within MAPK cascade IMP
IMP: Inferred from mutant phenotype
16720880 MGI
acts upstream of or within aorta morphogenesis IGI
IGI: Inferred from genetic interaction
21364285 MGI
acts upstream of apoptotic process IGI
IGI: Inferred from genetic interaction
16245339 MGI
acts upstream of apoptotic process IMP
IMP: Inferred from mutant phenotype
16720880 MGI
acts upstream of or within blood vessel remodeling IGI
IGI: Inferred from genetic interaction
17000704 MGI
acts upstream of or within branching involved in blood vessel morphogenesis IGI
IGI: Inferred from genetic interaction
15996652 MGI
acts upstream of or within branching involved in salivary gland morphogenesis IGI
IGI: Inferred from genetic interaction
15042696 MGI
acts upstream of or within branching involved in salivary gland morphogenesis IMP
IMP: Inferred from mutant phenotype
15063181 MGI
acts upstream of or within branching involved in ureteric bud morphogenesis IMP
IMP: Inferred from mutant phenotype
16049111 MGI
acts upstream of or within cell fate commitment IGI
IGI: Inferred from genetic interaction
15809037 MGI
acts upstream of or within cell migration involved in mesendoderm migration IMP
IMP: Inferred from mutant phenotype
10421635 MGI
acts upstream of cell population proliferation IGI
IGI: Inferred from genetic interaction
16245339 MGI
acts upstream of cell population proliferation IMP
IMP: Inferred from mutant phenotype
16720880 MGI
acts upstream of or within cell proliferation in forebrain IMP
IMP: Inferred from mutant phenotype
16613831 MGI
acts upstream of or within corticotropin hormone secreting cell differentiation IDA
IDA: Inferred from direct assay
9463347 MGI
acts upstream of or within determination of left/right symmetry IMP
IMP: Inferred from mutant phenotype
10411502 MGI
acts upstream of or within embryo development ending in birth or egg hatching IMP
IMP: Inferred from mutant phenotype
14623825 MGI
acts upstream of or within embryonic heart tube development IMP
IMP: Inferred from mutant phenotype
16720879 MGI
acts upstream of or within embryonic hindlimb morphogenesis IGI
IGI: Inferred from genetic interaction
16245339 MGI
acts upstream of or within embryonic neurocranium morphogenesis IGI
IGI: Inferred from genetic interaction
27395007 MGI
acts upstream of or within epithelial to mesenchymal transition involved in endocardial cushion formation IDA
IDA: Inferred from direct assay
21364285 MGI
involved in epithelial to mesenchymal transition involved in endocardial cushion formation IMP
IMP: Inferred from mutant phenotype
19509466 MGI
acts upstream of or within fibroblast growth factor receptor signaling pathway IDA
IDA: Inferred from direct assay
9435295 MGI
acts upstream of or within fibroblast growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
16245339 MGI
acts upstream of or within forebrain dorsal/ventral pattern formation IMP
IMP: Inferred from mutant phenotype
16613831 MGI
acts upstream of or within forebrain morphogenesis IMP
IMP: Inferred from mutant phenotype
16613831 MGI
acts upstream of or within generation of neurons IMP
IMP: Inferred from mutant phenotype
16267092 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
16720879 MGI
acts upstream of or within heart looping IMP
IMP: Inferred from mutant phenotype
10411502 MGI
acts upstream of or within heart morphogenesis IMP
IMP: Inferred from mutant phenotype
16696966 MGI
acts upstream of or within inner ear morphogenesis IGI
IGI: Inferred from genetic interaction
15809037 MGI
acts upstream of or within kidney development IMP
IMP: Inferred from mutant phenotype
16049111 MGI
acts upstream of or within larynx morphogenesis IGI
IGI: Inferred from genetic interaction
28177282 MGI
acts upstream of or within limb morphogenesis IGI
IGI: Inferred from genetic interaction
15328019 MGI
acts upstream of or within lung development IMP
IMP: Inferred from mutant phenotype
10411502 MGI
acts upstream of or within lung morphogenesis IMP
IMP: Inferred from mutant phenotype
10411502 MGI
acts upstream of or within male genitalia development IDA
IDA: Inferred from direct assay
12783783 MGI
acts upstream of or within mesodermal cell migration IMP
IMP: Inferred from mutant phenotype
10421635 MGI
acts upstream of or within midbrain-hindbrain boundary development IMP
IMP: Inferred from mutant phenotype
17601531 MGI
acts upstream of mitotic nuclear division IDA
IDA: Inferred from direct assay
12783783 MGI
acts upstream of or within negative regulation of apoptotic process IGI
IGI: Inferred from genetic interaction
16245339 MGI
acts upstream of or within negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
16613831 MGI
acts upstream of or within negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
16245339 MGI
acts upstream of or within neural plate morphogenesis IMP
IMP: Inferred from mutant phenotype
16613831 MGI
acts upstream of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
16245339 MGI
acts upstream of organ growth IGI
IGI: Inferred from genetic interaction
19389367 MGI
acts upstream of organ growth IMP
IMP: Inferred from mutant phenotype
19389367 MGI
acts upstream of or within organ induction IGI
IGI: Inferred from genetic interaction
15741321 MGI
acts upstream of or within otic vesicle formation IGI
IGI: Inferred from genetic interaction
17601531 MGI
acts upstream of or within outflow tract morphogenesis IGI
IGI: Inferred from genetic interaction
21364285 MGI
involved in outflow tract septum morphogenesis IGI
IGI: Inferred from genetic interaction
20807544 MGI
acts upstream of or within pallium development IMP
IMP: Inferred from mutant phenotype
16613831 MGI
acts upstream of or within pharyngeal system development IGI
IGI: Inferred from genetic interaction
21364285 MGI
acts upstream of or within positive regulation of ERK1 and ERK2 cascade IGI
IGI: Inferred from genetic interaction
24431450 MGI
acts upstream of or within positive regulation of G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
19307307 MGI
acts upstream of or within positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
9463347 MGI
acts upstream of or within positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
16720880 MGI
acts upstream of or within positive regulation of gene expression IDA
IDA: Inferred from direct assay
9244299 MGI
acts upstream of or within positive regulation of gene expression IGI
IGI: Inferred from genetic interaction
9847236 MGI
acts upstream of or within positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
10411502 MGI
acts upstream of or within positive regulation of mitotic nuclear division IDA
IDA: Inferred from direct assay
12783783 MGI
acts upstream of or within positive regulation of organ growth IGI
IGI: Inferred from genetic interaction
19389367 MGI
acts upstream of or within positive regulation of organ growth IMP
IMP: Inferred from mutant phenotype
19389367 MGI
acts upstream of or within positive regulation of peptidyl-tyrosine phosphorylation IMP
IMP: Inferred from mutant phenotype
16399079 MGI
acts upstream of or within positive regulation of stem cell proliferation IGI
IGI: Inferred from genetic interaction
16245339 MGI
acts upstream of or within regulation of odontogenesis of dentin-containing tooth IGI
IGI: Inferred from genetic interaction
9244299 MGI
acts upstream of or within signal transduction involved in regulation of gene expression IDA
IDA: Inferred from direct assay
18462699 MGI
acts upstream of stem cell proliferation IGI
IGI: Inferred from genetic interaction
16245339 MGI
acts upstream of or within subpallium development IMP
IMP: Inferred from mutant phenotype
16613831 MGI
acts upstream of or within telencephalon development IMP
IMP: Inferred from mutant phenotype
16613831 MGI
acts upstream of or within thyroid gland development IGI
IGI: Inferred from genetic interaction
19389367 MGI
acts upstream of or within thyroid gland development IMP
IMP: Inferred from mutant phenotype
19389367 MGI
acts upstream of or within thyroid-stimulating hormone-secreting cell differentiation IDA
IDA: Inferred from direct assay
9463347 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

fibroblast growth factor 8

  • androgen-induced growth factor

  • fibroblast growth factor 6c

  • heparin-binding growth factor 8

Recombinant Fgf8 Proteins

Cat. No. Product Name Accession Purity
HY-P7348 FGF-8c Protein, Mouse P37237 (Q23-R268) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P70533 FGF-8b Protein, Human/Mouse P55075-3/P37237-2 (Q23-R215) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700070AF Animal-Free FGF-8b Protein, Human/Mouse (His) P55075-3/P37237-2 (Q34-R215) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P7348A FGF-8c Protein, Mouse (His) P37237 (Q23-R268) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04906 FGF8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174692 Human FGF8 mRNA / Unkown
HY-RS17743 Fgf8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24209 Fgf8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fgf8 NCBI NCBI:2253