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Fxr1 - FMR1 autosomal homolog 1 Gene

Also Known as Fxr1h; Fxr1p; 1110050J02Rik; 9530073J07Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 14359

Summary

Enables G-quadruplex RNA binding activity and mRNA 3'-UTR binding activity. Involved in skeletal muscle organ development. Acts upstream of or within muscle organ development and negative regulation of translation. Located in several cellular components, including costamere; dendritic spine; and glutamatergic synapse. Part of polysome. Is expressed in several structures, including central nervous system; gut; musculature; sensory organ; and urinary system. Orthologous to human FXR1 (FMR1 autosomal homolog 1). [provided by Alliance of Genome Resources, Apr 2022]

Fxr1 Products (3)

mRNA	Protein	Name
NM_001113188.1	NP_001106659.1	RNA-binding protein FXR1 isoform 1
NM_001113189.1	NP_001106660.1	RNA-binding protein FXR1 isoform 2
NM_008053.2	NP_032079.1	RNA-binding protein FXR1 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables mRNA 3'-UTR AU-rich region binding	IDA IDA: Inferred from direct assay	15548538	MGI
enables mRNA binding	IDA IDA: Inferred from direct assay	28204491	MGI
enables molecular condensate scaffold activity	IDA IDA: Inferred from direct assay	32328638	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10567518	MGI
enables ribonucleoprotein complex binding	IDA IDA: Inferred from direct assay	11178106	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in dentate gyrus development	IMP IMP: Inferred from mutant phenotype	28204491	MGI
involved in muscle organ development	IDA IDA: Inferred from direct assay	32328638	MGI
acts upstream of or within muscle organ development	IMP IMP: Inferred from mutant phenotype	15128702	MGI
involved in muscle organ development	IMP IMP: Inferred from mutant phenotype	30770808	MGI
involved in negative regulation of long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	25456134	MGI
involved in negative regulation of translation	IDA IDA: Inferred from direct assay	25456134	MGI
involved in negative regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	15548538	MGI
involved in non-membrane-bounded organelle assembly	IDA IDA: Inferred from direct assay	35951695	MGI
involved in positive regulation of translation	IDA IDA: Inferred from direct assay	35951695	MGI
involved in post-transcriptional regulation of gene expression	IDA IDA: Inferred from direct assay	15548538	MGI
involved in post-transcriptional regulation of gene expression	IMP IMP: Inferred from mutant phenotype	32893934	MGI
involved in regulation of circadian sleep/wake cycle, sleep	IMP IMP: Inferred from mutant phenotype	32893934	MGI
involved in regulation of neurogenesis	IDA IDA: Inferred from direct assay	28204491	MGI
involved in regulation of synaptic transmission, glutamatergic	IMP IMP: Inferred from mutant phenotype	25456134	MGI
involved in skeletal muscle organ development	IDA IDA: Inferred from direct assay	30770808	MGI
involved in spermatid development	IDA IDA: Inferred from direct assay	35951695	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in axon	IDA IDA: Inferred from direct assay	22022532	MGI
located in costamere	IDA IDA: Inferred from direct assay	15128702	MGI
is active in cytoplasm	IDA IDA: Inferred from direct assay	35951695	MGI
located in cytosol	IDA IDA: Inferred from direct assay	30770808	MGI
located in dendrite	IDA IDA: Inferred from direct assay	22022532	MGI
located in dendritic spine	IDA IDA: Inferred from direct assay	22022532	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	27770568	MGI
is active in intracellular non-membrane-bounded organelle	IDA IDA: Inferred from direct assay	35951695	MGI
located in nucleus	IDA IDA: Inferred from direct assay	11178106	MGI
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	22022532	MGI
is active in postsynapse	IDA IDA: Inferred from direct assay	27770568	MGI
located in ribonucleoprotein granule	IDA IDA: Inferred from direct assay	22022532	MGI
located in ribosome	IDA IDA: Inferred from direct assay	22022532	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
RNA-binding protein FXR1 fragile X mental retardation syndrome-related protein 1

Protein Preferred Names

Protein Names

RNA-binding protein FXR1

fragile X mental retardation syndrome-related protein 1

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-14908A	Vidofludimus hemicalcium		/	Phase 2

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-14908	Vidofludimus		99.14%	Yes
HY-RS05163	FXR1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20736	Fxr1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27248	Fxr1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fxr1	NCBI	NCBI:8087