Gabra2 - gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2 Gene

Also Known as Gabra-2; C630048P16Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14395

Summary

Predicted to enable GABA-gated chloride ion channel activity; inhibitory extracellular ligand-gated ion channel activity; and transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to contribute to GABA-A receptor activity; benzodiazepine receptor activity; and Chloride Channel activity. Involved in inhibitory synapse assembly. Located in several cellular components, including dendrite; inhibitory synapse; and neuronal cell body. Is integral component of postsynaptic specialization membrane. Is active in GABA-ergic synapse. Is expressed in brain and lens. Human ortholog(s) of this gene implicated in alcohol use disorder; autistic disorder; and developmental and epileptic encephalopathy 78. Orthologous to human GABRA2 (gamma-aminobutyric acid type A receptor subunit alpha2). [provided by Alliance of Genome Resources, Apr 2022]

Gabra2 Products (1)

mRNA Protein Name
NM_008066.4 NP_032092.1 gamma-aminobutyric acid receptor subunit alpha-2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
28978485 MGI
Biological Process GO Annotation Evidence References Source
involved in inhibitory synapse assembly IDA
IDA: Inferred from direct assay
27129275 MGI
Cellular Component GO Annotation Evidence References Source
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
14627650 MGI
located in axon IDA
IDA: Inferred from direct assay
9682826 MGI
located in dendrite IDA
IDA: Inferred from direct assay
24554721 MGI
located in inhibitory synapse IDA
IDA: Inferred from direct assay
24554721 MGI
located in neuronal cell body IDA
IDA: Inferred from direct assay
24554721 MGI
located in postsynapse IDA
IDA: Inferred from direct assay
24554721 MGI
is active in postsynaptic specialization membrane IDA
IDA: Inferred from direct assay
14627650 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

gamma-aminobutyric acid receptor subunit alpha-2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05210 GABRA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20551 Gabra2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27060 Gabra2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gabra2 NCBI NCBI:2555