Gad1 - glutamate decarboxylase 1 Gene

Also Known as EP10; Gad-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14415

Summary

The protein encoded by this gene is an enzyme that catalyzes the production of gamma-aminobutyric acid from L-glutamic acid. Alternative splicing of this gene results in two products, the predominant 67 kDa isoform and a smaller 25 kDa isoform. The smaller isoform is not thought to retain catalytic activity. [provided by RefSeq, Aug 2015]

Gad1 Products (2)

mRNA Protein Name
NM_001312900.1 NP_001299829.1 glutamate decarboxylase 1 isoform GAD25
NM_008077.5 NP_032103.2 glutamate decarboxylase 1 isoform GAD67

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables glutamate decarboxylase activity IMP
IMP: Inferred from mutant phenotype
9177246 MGI
Biological Process GO Annotation Evidence References Source
involved in gamma-aminobutyric acid biosynthetic process IMP
IMP: Inferred from mutant phenotype
9177246 MGI
acts upstream of or within locomotory exploration behavior IMP
IMP: Inferred from mutant phenotype
24952328 MGI
acts upstream of or within social behavior IMP
IMP: Inferred from mutant phenotype
24952328 MGI
Cellular Component GO Annotation Evidence References Source
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
21584649 MGI
is active in GABA-ergic synapse IMP
IMP: Inferred from mutant phenotype
21584649 MGI
located in axon IDA
IDA: Inferred from direct assay
12074840 MGI
located in axon terminus IDA
IDA: Inferred from direct assay
11064363 MGI
located in cell cortex IDA
IDA: Inferred from direct assay
11064363 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
15347806 MGI
located in inhibitory synapse IDA
IDA: Inferred from direct assay
24613359 MGI
located in neuron projection terminus IDA
IDA: Inferred from direct assay
12074840 MGI
is active in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
29960053 MGI
is active in presynapse IDA
IDA: Inferred from direct assay
21584649 MGI
is active in presynapse IMP
IMP: Inferred from mutant phenotype
21584649 MGI
located in presynaptic active zone IDA
IDA: Inferred from direct assay
12074840 MGI
located in synapse IDA
IDA: Inferred from direct assay
15479642 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glutamate decarboxylase 1

  • 67 kDa glutamic acid decarboxylase

  • glutamic acid decarboxylase 1

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0161A Duloxetine hydrochloride Inhibitor 99.97% Yes
HY-B0161 Duloxetine Inhibitor 99.92% Yes
HY-118901 Opipramol Antagonist 99.91% Unkown
HY-B0161AR Duloxetine hydrochloride (Standard) Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-122487 Troriluzole Modulator 99.70% Phase 3

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-Y0367R Maleic acid (Standard) Inhibitor 99.99% Unkown
HY-B0161S Duloxetine-d7 Inhibitor 97.32% Unkown
HY-RS17368 Gad1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-118901A Opipramol dihydrochloride Antagonist / Unkown
HY-122487A Troriluzole hydrochloride Modulator / Unkown
HY-B0161AS Duloxetine-d3 hydrochloride Inhibitor / Unkown
HY-B0161AS1 Duloxetine-d7 hydrochloride Inhibitor / Unkown
HY-RS05227 GAD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-B0161S3 Duloxetine-d5 oxalate Inhibitor / Unkown
HY-RS23822 Gad1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gad1 NCBI NCBI:2571