PRIMA1 - proline rich membrane anchor 1 Gene

Homo sapiens

Also known as PRIMA

Gene ID: 145270 | Gene type: protein coding

About PRIMA1

Cytogenetic location: 14q32.12 Genomic coordinates (GRCh38): 14:93,718,298-93,788,994 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele and 179 orthologues. Broad expression in esophagus (RPKM 7.2), endometrium (RPKM 3.8) and 19 other tissues.

Summary

The product of this gene functions to organize acetylcholinesterase (AChE) into tetramers, and to anchor AChE at neural cell membranes. [provided by RefSeq, Nov 2008]

PRIMA1 Products(1)

mRNA	Protein	Name
NM_178013.4	NP_821092.1	proline-rich membrane anchor 1 precursor

Protein Preferred Names

Protein Names

proline-rich membrane anchor 1

acetylcholinesterase membrane anchor precursor PRiMA

Related Diseases

Diseases

Alias

Li-Fraumeni Syndrome

Sarcoma Family Syndrome Of Li And Fraumeni	Sbla Syndrome
LFS	Li-Fraumeni Familiar Cancer Susceptibility Syndrome
Sarcoma, Breast, Leukaemia And Adrenal Gland Syndrome	Lfs1
Li Fraumeni Syndrome	Sarcoma, Breast, Leukemia, And Adrenal Gland Syndrome
Lfl	Sbla Syndrome Li-Fraumeni-Like Syndrome
Li-Fraumeni Syndrome 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-19980	Eprenetapopt		≥99.0%	Phase 3

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19980A	PRIMA-1		≥98.0%	Unkown
HY-122578	P53R3	p53 Inhibitor	99.94%	Unkown
HY-RS11098	PRIMA1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PRIMA1	RGD	RGD:1583978
Mus musculus	PRIMA1	MGD	MGI:1926097
Bos taurus	PRIMA1	VGNC	VGNC:53948
Canis familiaris	PRIMA1	VGNC	VGNC:51672

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