Gdf5 - growth differentiation factor 5 Gene

Also Known as bp; brp; BMP-14; Cdmp-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14563

Summary

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates the development of numerous tissue and cell types, including cartilage, joints, brown fat, teeth, and the growth of neuronal axons and dendrites. Mice with a mutation in this gene exhibit enhanced tooth enamel formation. [provided by RefSeq, Aug 2016]

Gdf5 Products (1)

mRNA Protein Name
NM_008109.4 NP_032135.2 growth/differentiation factor 5 preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
14660436 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cell surface receptor protein serine/threonine kinase signaling pathway IGI
IGI: Inferred from genetic interaction
18363966 MGI
acts upstream of chondrocyte differentiation IDA
IDA: Inferred from direct assay
9885252 MGI
acts upstream of or within embryonic limb morphogenesis IMP
IMP: Inferred from mutant phenotype
15542031 MGI
acts upstream of or within forelimb morphogenesis IMP
IMP: Inferred from mutant phenotype
8145850 MGI
acts upstream of or within hindlimb morphogenesis IMP
IMP: Inferred from mutant phenotype
8145850 MGI
acts upstream of mesenchymal cell apoptotic process IMP
IMP: Inferred from mutant phenotype
15542031 MGI
acts upstream of or within negative regulation of mesenchymal cell apoptotic process IMP
IMP: Inferred from mutant phenotype
15542031 MGI
acts upstream of or within positive regulation of chondrocyte differentiation IDA
IDA: Inferred from direct assay
9885252 MGI
acts upstream of or within positive regulation of chondrocyte differentiation IGI
IGI: Inferred from genetic interaction
18363966 MGI
acts upstream of or within regulation of multicellular organism growth IMP
IMP: Inferred from mutant phenotype
17085896 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

growth/differentiation factor 5

  • bone morphogenetic protein 14

  • cartilage-derived morphogenetic protein-1

Recombinant Gdf5 Proteins

Cat. No. Product Name Accession Purity
HY-P79332 GDF-5 Protein, Mouse P43027 (A376-R495) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05355 GDF5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174775 Human BMPR1A mRNA / Unkown
HY-RS18243 Gdf5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24722 Gdf5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gdf5 NCBI NCBI:8200