Gpd2 - glycerol phosphate dehydrogenase 2, mitochondrial Gene

Also Known as GPDH; Gdm1; Gpd-m; Gpdh-m; TISP38

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14571

Summary

Predicted to enable glycerol-3-phosphate dehydrogenase [NAD+] activity. Acts upstream of or within camera-type eye development; gluconeogenesis; and glycerol-3-phosphate metabolic process. Located in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human GPD2 (glycerol-3-phosphate dehydrogenase 2). [provided by Alliance of Genome Resources, Apr 2022]

Gpd2 Products (2)

mRNA Protein Name
NM_001145820.1 NP_001139292.1 glycerol-3-phosphate dehydrogenase, mitochondrial precursor
NM_010274.3 NP_034404.3 glycerol-3-phosphate dehydrogenase, mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables glycerol-3-phosphate dehydrogenase (quinone) activity IMP
IMP: Inferred from mutant phenotype
9974390 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within camera-type eye development IGI
IGI: Inferred from genetic interaction
21296886 MGI
acts upstream of or within gluconeogenesis IMP
IMP: Inferred from mutant phenotype
12093800 MGI
acts upstream of or within glycerol-3-phosphate metabolic process IMP
IMP: Inferred from mutant phenotype
12093800 MGI
involved in glycerophosphate shuttle IMP
IMP: Inferred from mutant phenotype
9974390 MGI
acts upstream of or within multicellular organism growth IGI
IGI: Inferred from genetic interaction
21296886 MGI
Cellular Component GO Annotation Evidence References Source
is active in mitochondrial inner membrane IMP
IMP: Inferred from mutant phenotype
12093799 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glycerol-3-phosphate dehydrogenase, mitochondrial

  • FAD-linked glycerol-3-phosphate dehydrogenase

  • glycerol phosphate dehydrogenase 1, mitochondrial

  • glycerol-3-phosphate dehydrogenase 2, mitochondrial

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-148685 KM04416 Inhibitor 98.76% Unkown
HY-RS05635 GPD2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17954 Gpd2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24425 Gpd2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gpd2 NCBI NCBI:2820