Glra1 - glycine receptor, alpha 1 subunit Gene

Also Known as ot; spd; nmf11; spasmodic; oscillator

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14654

Summary

Enables extracellularly glycine-gated Chloride Channel activity; glycine binding activity; and transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential. Involved in glycinergic synaptic transmission; inhibitory postsynaptic potential; and response to alcohol. Acts upstream of or within several processes, including adult walking behavior; regulation of respiratory gaseous exchange by nervous system process; and righting reflex. Located in several cellular components, including external side of plasma membrane; glycinergic synapse; and inhibitory synapse. Is expressed in brain; brainstem; and spinal cord. Used to study hyperekplexia and hyperekplexia 1. Human ortholog(s) of this gene implicated in hyperekplexia 1. Orthologous to human GLRA1 (glycine receptor alpha 1). [provided by Alliance of Genome Resources, Apr 2022]

Glra1 Products (2)

mRNA Protein Name
NM_001290821.1 NP_001277750.1 glycine receptor subunit alpha-1 isoform 1 precursor
NM_020492.4 NP_065238.2 glycine receptor subunit alpha-1 isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables extracellularly glycine-gated chloride channel activity IDA
IDA: Inferred from direct assay
8062927 MGI
enables extracellularly glycine-gated chloride channel activity IMP
IMP: Inferred from mutant phenotype
16672662 MGI
enables glycine binding IDA
IDA: Inferred from direct assay
7874121 MGI
enables glycine binding IMP
IMP: Inferred from mutant phenotype
8062927 MGI
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IDA
IDA: Inferred from direct assay
28724750 MGI
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IMP
IMP: Inferred from mutant phenotype
28724750 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within acrosome reaction IMP
IMP: Inferred from mutant phenotype
11076688 MGI
acts upstream of or within adult walking behavior IMP
IMP: Inferred from mutant phenotype
17114051 MGI
acts upstream of or within chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
12837931 MGI
acts upstream of or within inhibitory postsynaptic potential IMP
IMP: Inferred from mutant phenotype
17114051 MGI
involved in inhibitory postsynaptic potential IMP
IMP: Inferred from mutant phenotype
24801766 MGI
acts upstream of or within neuromuscular process IMP
IMP: Inferred from mutant phenotype
9087981 MGI
acts upstream of or within neuromuscular process controlling posture IMP
IMP: Inferred from mutant phenotype
17114051 MGI
acts upstream of or within neuronal action potential IMP
IMP: Inferred from mutant phenotype
11742725 MGI
acts upstream of or within regulation of membrane potential IDA
IDA: Inferred from direct assay
8062927 MGI
acts upstream of or within regulation of membrane potential IMP
IMP: Inferred from mutant phenotype
16672662 MGI
acts upstream of or within regulation of respiratory gaseous exchange IMP
IMP: Inferred from mutant phenotype
11742725 MGI
acts upstream of or within regulation of respiratory gaseous exchange by nervous system process IMP
IMP: Inferred from mutant phenotype
16800867 MGI
involved in response to alcohol IMP
IMP: Inferred from mutant phenotype
24801766 MGI
acts upstream of or within righting reflex IMP
IMP: Inferred from mutant phenotype
17114051 MGI
acts upstream of or within startle response IMP
IMP: Inferred from mutant phenotype
8406478 MGI
acts upstream of or within synaptic transmission, glycinergic IMP
IMP: Inferred from mutant phenotype
16672662 MGI
involved in synaptic transmission, glycinergic IMP
IMP: Inferred from mutant phenotype
24801766 MGI
acts upstream of or within visual perception IMP
IMP: Inferred from mutant phenotype
17114051 MGI
Cellular Component GO Annotation Evidence References Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
17145751 MGI
is active in glycinergic synapse IDA
IDA: Inferred from direct assay
28724750 MGI
is active in glycinergic synapse IMP
IMP: Inferred from mutant phenotype
28724750 MGI
located in inhibitory synapse IDA
IDA: Inferred from direct assay
9812897 MGI
located in intracellular anatomical structure IDA
IDA: Inferred from direct assay
17145751 MGI
located in membrane IDA
IDA: Inferred from direct assay
1371219 MGI
located in neuron projection IDA
IDA: Inferred from direct assay
24801766 MGI
located in neuronal cell body IDA
IDA: Inferred from direct assay
24801766 MGI
located in postsynaptic membrane IDA
IDA: Inferred from direct assay
16964444 MGI
located in synapse IDA
IDA: Inferred from direct assay
24801766 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glycine receptor subunit alpha-1

  • glycine receptor 48 kDa subunit

  • glycine receptor strychnine-binding subunit

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05492 GLRA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22528 Glra1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29048 Glra1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Glra1 NCBI NCBI:2741