UPP2 - uridine phosphorylase 2 Gene

Also Known as UP2; UPASE2; UDRPASE2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 151531

About UPP2

Cytogenetic location: 2q24.1 Genomic coordinates (GRCh38): 2:157,995,179-158,136,154 (from NCBI)

This gene has 4 transcripts (splice variants), 187 orthologues and 1 paralogue. Restricted expression toward kidney (RPKM 10.8).

Summary

Enables deoxyuridine Phosphorylase activity; identical protein binding activity; and uridine Phosphorylase activity. Involved in dCMP catabolic process and uridine catabolic process. Located in type III intermediate filament. [provided by Alliance of Genome Resources, Apr 2022]

UPP2 Products (2)

mRNA	Protein	Name
NM_001135098.2	NP_001128570.1	uridine phosphorylase 2 isoform b
NM_173355.4	NP_775491.1	uridine phosphorylase 2 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables deoxyuridine phosphorylase activity	IDA IDA: Inferred from direct assay	12849978	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	21855639	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables uridine phosphorylase activity	IDA IDA: Inferred from direct assay	12849978	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in dCMP catabolic process	IDA IDA: Inferred from direct assay	12849978	GOA
involved in uridine catabolic process	IDA IDA: Inferred from direct assay	12849978	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in type III intermediate filament	IDA IDA: Inferred from direct assay	11278417	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UPP2 Protein Structure

PNP_UDP_1

0
100
200
300
317 a.a.

Protein Preferred Names	Protein Names
uridine phosphorylase 2	UPase 2

UPP2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	UPP2	O95045	SIAH1	Homo sapiens	Q8IUQ4	Validated Y2H	25416956
Intra	UPP2	O95045	UPP2	Homo sapiens	O95045	Y2H Array	29892012
Intra	UPP2	O95045	SIAH1	Homo sapiens	Q8IUQ4	Y2H Array	25416956
Intra	UPP2	O95045	UPP2	Homo sapiens	O95045	Y2H Array	31515488
Intra	UPP2	O95045	CCZ1B	Homo sapiens	P86790	Anti Tag CoIP	33961781
Intra	UPP2	O95045	UPP2	Homo sapiens	O95045	Y2H Array	25416956
Intra	UPP2	O95045	SIAH1	Homo sapiens	Q8IUQ4	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Myopathy, Myosin Storage, Autosomal Dominant	MSMA Myopathy, Hyaline Body, Autosomal Dominant Myopathy With Lysis Of Type I Myofibrils Autosomal Dominant Hyaline Body Myopathy Hyaline Body Myopathy Autosomal Dominant
Terminal Osseous Dysplasia	Terminal Osseous Dysplasia And Pigmentary Defects Terminal Osseous Dysplasia-Pigmentary Defects Syndrome Todpd TOD Odpd Odpf Syndrome Osseous Dysplasia, Digital, With Facial Pigmentary Defects And Multiple Frenula Odpf Digital Osseous Dysplasia With Facial Pigmentary Defects And Multiple Frenula Terminal Osseous Dysplasia With Pigmentary Defects Dcd Digitocutaneous Dysplasia Terminal Osseous Dysplasia And Pigmentary Defect Syndrome Osseous Dysplasia And Pigmentary Defects
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-106406	Benzylacyclouridine		98.02%	Phase 4

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15491	UPP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21452	Upp2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27970	Upp2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	UPP2	VGNC	VGNC:79372
Rattus norvegicus	UPP2	RGD	RGD:1308188
Bos taurus	UPP2	VGNC	VGNC:36689
Mus musculus	UPP2	MGD	MGI:1923904
Others	UPP2	NCBI