Hcfc1 - host cell factor C1 Gene

Also Known as HCF; HCF1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15161

Summary

This gene encodes a transcription cofactor that regulates the progression of cell cycle and maintain the ability of embryonic stem cells to self-renew. The encoded protein is a large precursor that undergoes site-specific proteolytic cleavage to yield N- and C-terminal chains that form a non-covalent heterodimer. The encoded protein has been implicated in the regulation of expression of immediate early genes after herpes simplex virus Infection and glucose-stimulated secretion of Insulin by pancreatic beta cells. [provided by RefSeq, Aug 2015]

Hcfc1 Products (2)

mRNA Protein Name
NM_001411234.1 NP_001398163.1 host cell factor 1 isoform 1
NM_008224.5 NP_032250.2 host cell factor 1 isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
18836447 MGI
enables chromatin DNA binding IDA
IDA: Inferred from direct assay
22878500 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
22878500 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within blastocyst hatching IMP
IMP: Inferred from mutant phenotype
27869233 MGI
involved in release from viral latency IDA
IDA: Inferred from direct assay
9990006 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
9990006 MGI
located in nucleus IDA
IDA: Inferred from direct assay
9990006 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

host cell factor 1

  • VP16 accessory protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06042 HCFC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174788 HHV-1 UL48 mRNA / Unkown
HY-RS19688 Hcfc1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26182 Hcfc1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hcfc1 NCBI NCBI:3054