Hexb - hexosaminidase B Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15212

Summary

Enables beta-N-acetylhexosaminidase activity and identical protein binding activity. Involved in several processes, including astrocyte cell migration; positive regulation of transcription by RNA polymerase II; and regulation of cell shape. Acts upstream of or within several processes, including ganglioside catabolic process; male courtship behavior; and penetration of zona pellucida. Located in several cellular components, including extracellular space; lysosome; and secretory granule. Is expressed in several structures, including endocrine gland; eye; genitourinary system; nervous system; and sternum. Used to study Sandhoff disease. Human ortholog(s) of this gene implicated in Sandhoff disease and spinal muscular atrophy. Orthologous to human HEXB (hexosaminidase subunit beta). [provided by Alliance of Genome Resources, Apr 2022]

Hexb Products (1)

mRNA Protein Name
NM_010422.2 NP_034552.1 beta-hexosaminidase subunit beta precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables beta-N-acetylhexosaminidase activity IDA
IDA: Inferred from direct assay
7203014 MGI
enables beta-N-acetylhexosaminidase activity IGI
IGI: Inferred from genetic interaction
8896570 MGI
enables beta-N-acetylhexosaminidase activity IMP
IMP: Inferred from mutant phenotype
8789434 MGI
enables hexosaminidase activity IMP
IMP: Inferred from mutant phenotype
22451654 MGI
enables hydrolase activity IDA
IDA: Inferred from direct assay
19710420 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
8269854 MGI
Biological Process GO Annotation Evidence References Source
involved in astrocyte cell migration IMP
IMP: Inferred from mutant phenotype
15155903 MGI
involved in chondroitin sulfate catabolic process IMP
IMP: Inferred from mutant phenotype
22451654 MGI
involved in dermatan sulfate catabolic process IGI
IGI: Inferred from genetic interaction
11707436 MGI
acts upstream of or within ganglioside catabolic process IMP
IMP: Inferred from mutant phenotype
8566348 MGI
acts upstream of or within glycosaminoglycan metabolic process IGI
IGI: Inferred from genetic interaction
8896570 MGI
involved in glycosaminoglycan metabolic process IMP
IMP: Inferred from mutant phenotype
11707436 MGI
acts upstream of or within glycosphingolipid metabolic process IMP
IMP: Inferred from mutant phenotype
8789434 MGI
involved in hyaluronan catabolic process IMP
IMP: Inferred from mutant phenotype
22451654 MGI
acts upstream of or within intracellular calcium ion homeostasis IGI
IGI: Inferred from genetic interaction
12756243 MGI
acts upstream of or within intracellular calcium ion homeostasis IMP
IMP: Inferred from mutant phenotype
12756243 MGI
acts upstream of or within lipid storage IGI
IGI: Inferred from genetic interaction
10021458 MGI
acts upstream of or within lipid storage IMP
IMP: Inferred from mutant phenotype
7550345 MGI
acts upstream of or within locomotory behavior IGI
IGI: Inferred from genetic interaction
8896570 MGI
acts upstream of or within locomotory behavior IMP
IMP: Inferred from mutant phenotype
7550345 MGI
acts upstream of or within lysosome organization IGI
IGI: Inferred from genetic interaction
8896570 MGI
acts upstream of or within lysosome organization IMP
IMP: Inferred from mutant phenotype
8789434 MGI
acts upstream of or within maintenance of location in cell IMP
IMP: Inferred from mutant phenotype
7550345 MGI
acts upstream of or within male courtship behavior IMP
IMP: Inferred from mutant phenotype
12617783 MGI
acts upstream of or within myelination IGI
IGI: Inferred from genetic interaction
9184660 MGI
acts upstream of or within neuromuscular process IMP
IMP: Inferred from mutant phenotype
7550345 MGI
acts upstream of or within neuromuscular process controlling balance IGI
IGI: Inferred from genetic interaction
8896570 MGI
acts upstream of or within neuromuscular process controlling balance IMP
IMP: Inferred from mutant phenotype
7550345 MGI
acts upstream of or within neuron cellular homeostasis IGI
IGI: Inferred from genetic interaction
12756243 MGI
acts upstream of or within neuron cellular homeostasis IMP
IMP: Inferred from mutant phenotype
12756243 MGI
acts upstream of or within oligosaccharide catabolic process IMP
IMP: Inferred from mutant phenotype
10021458 MGI
acts upstream of or within oogenesis IMP
IMP: Inferred from mutant phenotype
9223328 MGI
acts upstream of or within penetration of zona pellucida IMP
IMP: Inferred from mutant phenotype
8269854 MGI
acts upstream of or within phospholipid biosynthetic process IMP
IMP: Inferred from mutant phenotype
15198669 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
15155903 MGI
acts upstream of or within protein metabolic process IMP
IMP: Inferred from mutant phenotype
12657883 MGI
involved in regulation of cell shape IMP
IMP: Inferred from mutant phenotype
15155903 MGI
acts upstream of or within regulation of cellular metabolic process IMP
IMP: Inferred from mutant phenotype
15198669 MGI
acts upstream of or within sensory perception of sound IGI
IGI: Inferred from genetic interaction
8896570 MGI
acts upstream of or within sexual reproduction IMP
IMP: Inferred from mutant phenotype
9645704 MGI
involved in single fertilization IDA
IDA: Inferred from direct assay
8253842 MGI
acts upstream of or within single fertilization IMP
IMP: Inferred from mutant phenotype
12756243 MGI
acts upstream of or within skeletal system development IGI
IGI: Inferred from genetic interaction
8896570 MGI
Cellular Component GO Annotation Evidence References Source
located in acrosomal vesicle IDA
IDA: Inferred from direct assay
8269854 MGI
located in cortical granule IDA
IDA: Inferred from direct assay
8253842 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
19710420 MGI
is active in lysosome IDA
IDA: Inferred from direct assay
8286571 MGI
located in lysosome IDA
IDA: Inferred from direct assay
11854359 MGI
is active in lysosome IMP
IMP: Inferred from mutant phenotype
22451654 MGI
located in membrane IDA
IDA: Inferred from direct assay
11854359 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

beta-hexosaminidase subunit beta

  • N-acetyl-beta-glucosaminidase subunit beta

  • beta-N-acetylhexosaminidase subunit beta

  • hexosaminidase subunit B

Recombinant Hexb Proteins

Cat. No. Product Name Accession Purity
HY-P75808 HEXB/Hexosaminidase B Protein, Mouse (HEK293, His) P20060 (Q32-I536) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-104050 M-31850 99.79% Unkown
HY-108241A Galacto-PUGNAc Inhibitor / Unkown
HY-175076 Globotriaosylceramide (non-hydroxy) (porcine RBC) / Unkown
HY-RS06143 HEXB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-N12056 Cyclo(L-leucyl-L-valyl) 99.35% Unkown
HY-RS18135 Hexb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24610 Hexb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hexb NCBI NCBI:3074