Nr4a1 - nuclear receptor subfamily 4, group A, member 1 Gene

Also Known as Hmr; N10; TR3; Gfrp; Hbr1; NP10; TIS1; GFRP1; Hbr-1; NGFIB; nur77; NGFI-B; NUR77-1; NUR77-2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15370

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; identical protein binding activity; and sequence-specific DNA binding activity. Involved in cellular response to corticotropin-releasing hormone stimulus; fat cell differentiation; and negative regulation of cell cycle. Acts upstream of or within several processes, including positive regulation of transcription by RNA polymerase II; regulation of apoptotic process; and skeletal muscle cell differentiation. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including bone; genitourinary system; hemolymphoid system; nervous system; and submandibular gland primordium. Orthologous to human NR4A1 (nuclear receptor subfamily 4 group A member 1). [provided by Alliance of Genome Resources, Apr 2022]

Nr4a1 Products (6)

mRNA Protein Name
NM_001411253.1 NP_001398182.1 nuclear receptor subfamily 4 group A member 1
NM_001411254.1 NP_001398183.1 nuclear receptor subfamily 4 group A member 1
NM_010444.3 NP_034574.1 nuclear receptor subfamily 4 group A member 1
NM_001411253.1 NP_001398182.1 nuclear receptor subfamily 4 group A member 1
NM_001411254.1 NP_001398183.1 nuclear receptor subfamily 4 group A member 1
NM_010444.3 NP_034574.1 nuclear receptor subfamily 4 group A member 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
18292087 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
9155013 MGI
enables double-stranded DNA binding IDA
IDA: Inferred from direct assay
37001519 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
18388149 MGI
enables lipopolysaccharide binding IDA
IDA: Inferred from direct assay
37001519 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
8961274 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
8961274 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within apoptotic process IMP
IMP: Inferred from mutant phenotype
17434920 MGI
involved in cellular response to corticotropin-releasing hormone stimulus IDA
IDA: Inferred from direct assay
10523643 MGI
involved in detection of lipopolysaccharide IDA
IDA: Inferred from direct assay
37001519 MGI
involved in fat cell differentiation IDA
IDA: Inferred from direct assay
18945812 MGI
involved in negative regulation of cell cycle IDA
IDA: Inferred from direct assay
18945812 MGI
acts upstream of or within negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
IDA: Inferred from direct assay
12815108 MGI
involved in non-canonical inflammasome complex assembly IMP
IMP: Inferred from mutant phenotype
37001519 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
8961274 MGI
acts upstream of or within positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
14657025 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
8961274 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
15155786 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
28775000 MGI
acts upstream of or within skeletal muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
22147266 MGI
acts upstream of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
15155786 MGI
Cellular Component GO Annotation Evidence References Source
located in chromatin IDA
IDA: Inferred from direct assay
30134173 MGI
located in cytosol IDA
IDA: Inferred from direct assay
37001519 MGI
located in nucleus IDA
IDA: Inferred from direct assay
12815108 MGI
part of transcription regulator complex IDA
IDA: Inferred from direct assay
9155013 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nuclear receptor subfamily 4 group A member 1

  • hormone receptor

  • nuclear hormone receptor NUR/77

  • nuclear protein N10

  • orphan nuclear receptor HMR

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P1624 Teduglutide Activator 99.85% Unkown
HY-P1624A Teduglutide TFA Activator / Unkown

Pre-clinical Phase

Bioactive Molecules (15)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N2148 Cytosporone B Agonist 99.23% Unkown
HY-112055 DIM-C-pPhOH 98.88% Unkown
HY-159779 NR-V04 Degrader 99.90% Unkown
HY-P2917 Glycerol kinase, microorganism Inhibitor 98.00% Unkown
HY-112056 DIM-C-pPhCO2Me 99.47% Unkown
HY-179528 DIM-3,5-Cl2 99.18% Unkown
HY-160498 Amoitone B Agonist 98.50% Unkown
HY-P1624S1 Teduglutide-Leu(13C6,15N) sodium 96.60% Unkown
HY-RS09550 NR4A1 Human Pre-designed siRNA Set A / Unkown
HY-RS16573 Nr4a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23006 Nr4a1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-179112 PROTAC IKKβ/NR4A1 degrader-1 / Unkown
HY-175725 NR4A1 agonist 1 Agonist / Unkown
HY-181588 NR4A agonist-2 Agonist / Unkown
HY-P1624S Teduglutide-Ala(13C3,15N) sodium / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nr4a1 NCBI NCBI:3164