Hnf4a - hepatic nuclear factor 4, alpha Gene

Also Known as Hnf4; HNF-4; MODY1; Nr2a1; Tcf14; TCF-14; Hnf4alpha

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15378

Summary

The protein encoded by this gene is a transcription factor involved in the development of the pancreas, liver, kidney, and intestines. The encoded protein also functions to maintain glucose homeostasis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]

Hnf4a Products (3)

mRNA Protein Name
NM_001312906.1 NP_001299835.1 hepatocyte nuclear factor 4-alpha isoform HNF4alpha11
NM_001312907.1 NP_001299836.1 hepatocyte nuclear factor 4-alpha isoform HNF4alpha10
NM_008261.3 NP_032287.2 hepatocyte nuclear factor 4-alpha isoform HNF4alpha2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
15014077 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
27471003 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
15761495 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
10859308 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
22589549 MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
17932483 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
22780989 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17636037 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
8306889 MGI
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
15761495 MGI
Biological Process GO Annotation Evidence References Source
involved in cholesterol homeostasis IMP
IMP: Inferred from mutant phenotype
11158324 MGI
involved in glucose homeostasis IMP
IMP: Inferred from mutant phenotype
15761495 MGI
acts upstream of or within lipid metabolic process IMP
IMP: Inferred from mutant phenotype
16498401 MGI
involved in phospholipid homeostasis IMP
IMP: Inferred from mutant phenotype
11158324 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
9408084 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
30555544 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
10859308 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15761495 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
17636037 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
16537911 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
11158324 MGI
acts upstream of or within regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
9053305 MGI
involved in regulation of circadian rhythm IMP
IMP: Inferred from mutant phenotype
30530698 MGI
acts upstream of or within regulation of gastrulation IMP
IMP: Inferred from mutant phenotype
7958910 MGI
involved in regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
15761495 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
22589549 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
22589549 MGI
involved in response to glucose IMP
IMP: Inferred from mutant phenotype
15761495 MGI
acts upstream of or within sex differentiation IMP
IMP: Inferred from mutant phenotype
17412818 MGI
acts upstream of or within signal transduction involved in regulation of gene expression IDA
IDA: Inferred from direct assay
18462699 MGI
acts upstream of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
10859308 MGI
involved in triglyceride homeostasis IMP
IMP: Inferred from mutant phenotype
11158324 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
8306889 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

hepatocyte nuclear factor 4-alpha

  • HNF4 alpha

  • Nuclear receptor 2A1

  • nuclear receptor subfamily 2 group A member 1

  • transcription factor 14

  • transcription factor HNF-4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-176847 DHQZ-17 99.58% Unkown
HY-RS06257 HNF4A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17608 Hnf4a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24068 Hnf4a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06255 HNF1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hnf4a NCBI NCBI:3172