Hrh2 - histamine receptor H2 Gene

Also Known as H2R; HH2R

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15466

About Hrh2

Chromosome 13: 54,346,148-54,390,199 forward strand.GRCm39:CM001006.3

This gene has 3 transcripts (splice variants), 249 orthologues, 32 paralogues and is associated with 15 phenotypes. Broad expression in frontal lobe adult (RPKM 1.9), stomach adult (RPKM 1.8) and 18 other tissues.

Summary

Predicted to enable G protein-coupled amine receptor activity; heterocyclic compound binding activity; and neurotransmitter receptor activity. Acts upstream of or within several processes, including gastric acid secretion; learning or memory; and toxin transport. Predicted to be located in membrane. Predicted to be active in dendrite. Predicted to be integral component of plasma membrane. Is expressed in brain; early conceptus; stomach; and uterus. Orthologous to human HRH2 (Histamine Receptor H2). [provided by Alliance of Genome Resources, Apr 2022]

Hrh2 Products (2)

mRNA Protein Name
NM_001413010.1 NP_001399939.1 histamine H2 receptor isoform 3
NM_001010973.3 NP_001010973.1 histamine H2 receptor isoform 1

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within digestive tract development IMP
IMP: Inferred from mutant phenotype
10862789 MGI
acts upstream of or within epithelial cell morphogenesis IMP
IMP: Inferred from mutant phenotype
10862789 MGI
acts upstream of or within gastric acid secretion IGI
IGI: Inferred from genetic interaction
15476751 MGI
acts upstream of or within gastrin-induced gastric acid secretion IMP
IMP: Inferred from mutant phenotype
10862789 MGI
acts upstream of or within gland development IMP
IMP: Inferred from mutant phenotype
15476751 MGI
acts upstream of or within histamine-induced gastric acid secretion IMP
IMP: Inferred from mutant phenotype
10862789 MGI
acts upstream of or within memory IMP
IMP: Inferred from mutant phenotype
17145090 MGI
acts upstream of or within regulation of synaptic plasticity IMP
IMP: Inferred from mutant phenotype
17145090 MGI
acts upstream of or within visual learning IMP
IMP: Inferred from mutant phenotype
17145090 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Hrh2 Protein Structure

7tmA_Histamine_H2R

7tmA_Histamine_H2R: cd15051 (18 - 297)

7tmA_Histamine_H2R

7tmA_Histamine_H2R: cd15051 (19 - 45)

7tmA_Histamine_H2R

7tmA_Histamine_H2R: cd15051 (52 - 79)

7tmA_Histamine_H2R

7tmA_Histamine_H2R: cd15051 (90 - 120)

7tmA_Histamine_H2R

7tmA_Histamine_H2R: cd15051 (132 - 152)

7tmA_Histamine_H2R

7tmA_Histamine_H2R: cd15051 (177 - 207)

7tmA_Histamine_H2R

7tmA_Histamine_H2R: cd15051 (225 - 255)

7tmA_Histamine_H2R

7tmA_Histamine_H2R: cd15051 (265 - 290)

  • 0
  • 100
  • 200
  • 300
  • 397 a.a.
Protein Preferred Names Protein Names

histamine H2 receptor

  • gastric receptor I

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-170442 ECI830 Inhibitor 98.01% Phase 2

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-156959 Ovalicin Inhibitor / Unkown
HY-RS06362 HRH2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06363 Hrh2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06364 Hrh2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20393 Dhx15 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hrh2 NCBI NCBI:3274