Cfh - complement factor H Gene

Also Known as Fh; AMBP1; AMBP-1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 155012

Summary

Predicted to enable several functions, including complement component C3b binding activity; heparan sulfate proteoglycan binding activity; and heparin binding activity. Involved in several processes, including cellular response to hydrogen peroxide; cellular response to interferon-gamma; and cellular response to lipopolysaccharide. Located in several cellular components, including extracellular space; nucleus; and plasma membrane. Used to study atypical hemolytic-uremic syndrome. Biomarker of amphetamine abuse; membranous glomerulonephritis; obstructive jaundice; proteinuria (multiple); and retinal degeneration. Human ortholog(s) of this gene implicated in several diseases, including atypical hemolytic-uremic syndrome; eye disease (multiple); hemolytic-uremic syndrome; lupus nephritis; and systemic lupus erythematosus. Orthologous to several human genes including CFH (complement Factor H). [provided by Alliance of Genome Resources, Apr 2022]

Cfh Products (1)

mRNA Protein Name
NM_130409.2 NP_569093.2 complement factor H precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in cellular response to hydrogen peroxide IEP
IEP: Inferred from expression pattern
20484586 RGD
involved in cellular response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
12121434 RGD
involved in cellular response to type II interferon IEP
IEP: Inferred from expression pattern
12121434 RGD
involved in complement activation IEP
IEP: Inferred from expression pattern
12911541 RGD
involved in regulation of complement activation IDA
IDA: Inferred from direct assay
12374811 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
12911541 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

complement factor H

  • adrenomedullin binding protein-1

  • complement component factor H

  • complement inhibitory factor H

  • platelet complement factor H

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P991954 GT103 Inhibitor / Phase 2

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02561 CFH Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17522 Cfh Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23978 Cfh Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cfh NCBI NCBI:3075