Hspa2 - heat shock protein 2 Gene

Also Known as 70kDa; HSP70.2; HSP70A2; Hsp70-2

Species: Mus musculus

Gene Type: protein coding

Gene ID: 15512

Summary

Enables glycolipid binding activity. Involved in positive regulation of ATPase activity; positive regulation of ATPase-coupled calcium transmembrane transporter activity; and spermatogenesis. Acts upstream of or within several processes, including male gamete generation; positive regulation of G2/M transition of mitotic cell cycle; and synaptonemal complex disassembly. Located in cell surface; meiotic spindle; and nucleus. Part of CatSper complex. Is expressed in alimentary system; ganglia; medulla oblongata basal plate; testis; and vibrissa. Orthologous to human HSPA2 (heat shock protein family A (HSP70) member 2). [provided by Alliance of Genome Resources, Apr 2022]

Hspa2 Products (4)

mRNA	Protein	Name
NM_001002012.2	NP_001002012.1	heat shock-related 70 kDa protein 2
NM_001409571.1	NP_001396500.1	heat shock-related 70 kDa protein 2
NM_001409572.1	NP_001396501.1	heat shock-related 70 kDa protein 2
NM_008301.5	NP_032327.2	heat shock-related 70 kDa protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables glycolipid binding	IDA IDA: Inferred from direct assay	9337084	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9247342	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within male meiosis I	IMP IMP: Inferred from mutant phenotype	9409676	MGI
acts upstream of or within male meiotic nuclear division	IMP IMP: Inferred from mutant phenotype	8622925	MGI
involved in positive regulation of ATP-dependent activity	IMP IMP: Inferred from mutant phenotype	22495301	MGI
involved in positive regulation of ATPase-coupled calcium transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	22495301	MGI
acts upstream of or within positive regulation of G2/M transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	9247342	MGI
acts upstream of or within positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	9247342	MGI
acts upstream of or within spermatid development	IMP IMP: Inferred from mutant phenotype	8622925	MGI
involved in spermatogenesis	IMP IMP: Inferred from mutant phenotype	24557841	MGI
acts upstream of or within synaptonemal complex disassembly	IMP IMP: Inferred from mutant phenotype	9409676	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of CatSper complex	IDA IDA: Inferred from direct assay	21224844	MGI
located in cell surface	IDA IDA: Inferred from direct assay	9337084	MGI
located in male germ cell nucleus	IDA IDA: Inferred from direct assay	17035236	MGI
located in meiotic spindle	IDA IDA: Inferred from direct assay	24557841	MGI
located in synaptonemal complex	IDA IDA: Inferred from direct assay	8622925	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
heat shock-related 70 kDa protein 2	heat shock 70kDa protein 2 heat shock protein 70.2 heat shock protein, 70 kDa 2

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-152153	GRP78-IN-3	Inhibitor	99.88%	Unkown
HY-RS06427	HSPA2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20423	Hspa2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25750	Hspa1b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26932	Hspa2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hspa2	NCBI	NCBI:3306