Htr1a - 5-hydroxytryptamine (serotonin) receptor 1A Gene

Also Known as Gpcr18

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15550

About Htr1a

Chromosome 13: 105,580,147-105,584,630 forward strand.GRCm39:CM001006.3

This gene has 1 transcript (splice variant), 149 orthologues, 32 paralogues and is associated with 12 phenotypes.

Summary

Enables G protein-coupled serotonin receptor activity. Involved in several processes, including behavioral fear response; serotonin metabolic process; and serotonin receptor signaling pathway. Acts upstream of or within gamma-aminobutyric acid signaling pathway. Predicted to be located in axon hillock. Predicted to be active in dendrite. Predicted to be integral component of plasma membrane. Is expressed in several structures, including central nervous system; exocrine gland; eye; genitourinary system; and intestine. Used to study anxiety disorder. Human ortholog(s) of this gene implicated in anxiety disorder; mental depression; and panic disorder. Orthologous to human HTR1A (5-hydroxytryptamine receptor 1A). [provided by Alliance of Genome Resources, Apr 2022]

Htr1a Products (1)

mRNA Protein Name
NM_008308.5 NP_032334.2 5-hydroxytryptamine receptor 1A

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled serotonin receptor activity IDA
IDA: Inferred from direct assay
8254366 MGI
enables G protein-coupled serotonin receptor activity IMP
IMP: Inferred from mutant phenotype
9826725 MGI
Biological Process GO Annotation Evidence References Source
involved in behavioral fear response IMP
IMP: Inferred from mutant phenotype
9826725 MGI
involved in exploration behavior IMP
IMP: Inferred from mutant phenotype
9826725 MGI
acts upstream of or within gamma-aminobutyric acid signaling pathway IMP
IMP: Inferred from mutant phenotype
16925594 MGI
involved in regulation of dopamine metabolic process IMP
IMP: Inferred from mutant phenotype
11080193 MGI
involved in regulation of serotonin secretion IMP
IMP: Inferred from mutant phenotype
9826725 MGI
involved in serotonin metabolic process IMP
IMP: Inferred from mutant phenotype
11080193 MGI
involved in serotonin receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
9826725 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Htr1a Protein Structure

7tmA_5-HT1A_vertebrates

7tmA_5-HT1A_vertebrates: cd15330 (36 - 410)

7tmA_5-HT1A_vertebrates

7tmA_5-HT1A_vertebrates: cd15330 (37 - 63)

7tmA_5-HT1A_vertebrates

7tmA_5-HT1A_vertebrates: cd15330 (70 - 96)

7tmA_5-HT1A_vertebrates

7tmA_5-HT1A_vertebrates: cd15330 (108 - 138)

7tmA_5-HT1A_vertebrates

7tmA_5-HT1A_vertebrates: cd15330 (150 - 172)

7tmA_5-HT1A_vertebrates

7tmA_5-HT1A_vertebrates: cd15330 (191 - 220)

7tmA_5-HT1A_vertebrates

7tmA_5-HT1A_vertebrates: cd15330 (337 - 367)

7tmA_5-HT1A_vertebrates

7tmA_5-HT1A_vertebrates: cd15330 (378 - 403)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 421 a.a.
Protein Preferred Names Protein Names

5-hydroxytryptamine receptor 1A

  • 5-HT-1A

  • 5-HT1A receptor

  • G-protein coupled receptor 18

  • serotonin receptor 1A

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0735 Phellodendrine chloride 99.68% Unkown
HY-N0427 Phellodendrine 99.60% Unkown
HY-RS06458 HTR1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06459 Htr1a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06460 Htr1a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Htr1a NCBI NCBI:3350