Ifnb1 - interferon beta 1, fibroblast Gene

Also Known as Ifb; IFNB; If1da1; IFN-beta

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15977

Summary

Enables cytokine activity and type I interferon receptor binding activity. Involved in B cell proliferation; cellular response to virus; and type I interferon signaling pathway. Acts upstream of or within several processes, including cellular response to organic cyclic compound; defense response to Other organism; and negative regulation of osteoclast differentiation. Located in extracellular space. Is expressed in embryo and liver. Human ortholog(s) of this gene implicated in COVID-19. Orthologous to human IFNB1 (interferon beta 1). [provided by Alliance of Genome Resources, Apr 2022]

Ifnb1 Products (1)

mRNA Protein Name
NM_010510.2 NP_034640.1 interferon beta precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cytokine activity IDA
IDA: Inferred from direct assay
15240719 MGI
enables type I interferon receptor binding IPI
IPI: Inferred from physical interaction
23872679 MGI
Biological Process GO Annotation Evidence References Source
involved in B cell proliferation IMP
IMP: Inferred from mutant phenotype
14597717 MGI
acts upstream of or within adaptive immune response IDA
IDA: Inferred from direct assay
17277142 MGI
acts upstream of or within cellular response to dexamethasone stimulus IDA
IDA: Inferred from direct assay
21606371 MGI
involved in cellular response to dsRNA IEP
IEP: Inferred from expression pattern
18596219 MGI
involved in cellular response to virus IDA
IDA: Inferred from direct assay
24882218 MGI
acts upstream of or within defense response to bacterium IDA
IDA: Inferred from direct assay
15240719 MGI
acts upstream of or within defense response to virus IDA
IDA: Inferred from direct assay
17277142 MGI
involved in defense response to virus IDA
IDA: Inferred from direct assay
10708458 MGI
involved in defense response to virus IMP
IMP: Inferred from mutant phenotype
27129230 MGI
acts upstream of or within humoral immune response IDA
IDA: Inferred from direct assay
17277142 MGI
involved in negative regulation of Lewy body formation IMP
IMP: Inferred from mutant phenotype
26451483 MGI
acts upstream of or within negative regulation of osteoclast differentiation IDA
IDA: Inferred from direct assay
17442941 MGI
involved in neuron cellular homeostasis IMP
IMP: Inferred from mutant phenotype
26451483 MGI
involved in positive regulation of autophagy IMP
IMP: Inferred from mutant phenotype
26451483 MGI
involved in type I interferon-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
27129230 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
17277142 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

interferon beta

  • interferon 1da1

Recombinant Ifnb1 Proteins

Cat. No. Product Name Accession Purity
HY-P73130 IFN-beta Protein, Mouse (HEK293) P01575 (I22-N182) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P73131 IFN-beta Protein, Mouse (HEK293, Fc) P01575 (I22-N182) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-138682 STING-IN-2 Inhibitor 99.71% Unkown
HY-147129 cGAS-IN-9 Inhibitor / Unkown
HY-178951 STING-IN-17 Inhibitor / Unkown
HY-RS06585 IFNB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174664 Human IFNB1 mRNA / Unkown
HY-RS17301 Ifnb1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23756 Ifnb1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ifnb1 NCBI NCBI:3456