Il7r - interleukin 7 receptor Gene

Also Known as CD127; IL-7Ralpha

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16197

Summary

Interleukin-7 is a glycoptorein involved in the regulation of lymphopoiesis. Response of cells to IL7 is dependent on the presence of the interleukin 7 receptor (IL7R); the active receptor is a alpha/gamma chain heterodimer. The gamma(c) chain, which also associates with the interleukin-2 receptor, serves primarily to activate signal transduction by the IL7R complex, while the alpha chain of IL7R determines specific signaling events through its association with cytoplasmic signaling molecules. [provided by RefSeq, Jul 2008]

Il7r Products (2)

mRNA Protein Name
NM_001355680.1 NP_001342609.1 interleukin-7 receptor subunit alpha isoform 2 precursor
NM_008372.4 NP_032398.3 interleukin-7 receptor subunit alpha isoform 1 precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within B cell homeostasis IGI
IGI: Inferred from genetic interaction
15909309 MGI
acts upstream of or within B cell proliferation IGI
IGI: Inferred from genetic interaction
15909309 MGI
acts upstream of or within B cell proliferation IMP
IMP: Inferred from mutant phenotype
15909309 MGI
acts upstream of or within T cell differentiation IGI
IGI: Inferred from genetic interaction
9215624 MGI
acts upstream of or within T cell differentiation IMP
IMP: Inferred from mutant phenotype
9215624 MGI
acts upstream of T cell differentiation in thymus IMP
IMP: Inferred from mutant phenotype
9215626 MGI
acts upstream of or within T cell homeostasis IMP
IMP: Inferred from mutant phenotype
9215624 MGI
acts upstream of T cell mediated cytotoxicity IMP
IMP: Inferred from mutant phenotype
9215624 MGI
acts upstream of or within cell morphogenesis IGI
IGI: Inferred from genetic interaction
15909309 MGI
involved in defense response to Gram-positive bacterium IMP
IMP: Inferred from mutant phenotype
20364087 MGI
acts upstream of gene expression IMP
IMP: Inferred from mutant phenotype
18958875 MGI
acts upstream of or within immunoglobulin production IGI
IGI: Inferred from genetic interaction
15909309 MGI
acts upstream of or within lymph node development IMP
IMP: Inferred from mutant phenotype
12732660 MGI
acts upstream of or within negative regulation of T cell apoptotic process IMP
IMP: Inferred from mutant phenotype
9215624 MGI
acts upstream of or within negative regulation of T cell mediated cytotoxicity IMP
IMP: Inferred from mutant phenotype
9215624 MGI
acts upstream of or within positive regulation of T cell differentiation in thymus IMP
IMP: Inferred from mutant phenotype
9215626 MGI
acts upstream of or within positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
18958875 MGI
acts upstream of or within regulation of cell size IDA
IDA: Inferred from direct assay
15909309 MGI
acts upstream of or within regulation of cell size IGI
IGI: Inferred from genetic interaction
15909309 MGI
Cellular Component GO Annotation Evidence References Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
12714519 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

interleukin-7 receptor subunit alpha

  • IL-7 receptor alpha chain

  • IL-7 receptor subunit alpha

  • IL-7R subunit alpha

  • IL-7R-alpha

  • IL-7RA

  • interleukin 7 receptor alpha chain

Recombinant Il7r Proteins

Cat. No. Product Name Accession Purity
HY-P72536 CD127/IL-7RA Protein, Mouse (HEK293, Fc) P16872 (E21-D239) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P76436 CD127/IL-7RA Protein, Mouse (HEK293, His) P16872 (E21-D239) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P99412 Lusvertikimab Antagonist 99.41% Phase 2
HY-P990023 Bempikibart Antagonist 98.00% Phase 2

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-206870 BP79 Inhibitor / Unkown
HY-RS06780 IL7R Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174597 Human IL7R mRNA / Unkown
HY-RS16894 Il7r Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23336 Il7r Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990774 Verekitug Inhibitor 97.00% Unkown
HY-P990911 Crebankitug Inhibitor ≥99.0% Unkown
HY-P990209 Anti-Mouse IL-7Rα/CD127 Antibody (A7R34) Inhibitor 95.00% Unkown
HY-P991720 Tepilukimig Inhibitor 95.57% Unkown
HY-P991265 OSE-703 Inhibitor / Unkown
HY-P992447 QX008N Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il7r NCBI NCBI:3575