Inhba - inhibin beta-A Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16323

Summary

This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. The encoded protein also plays a role in eye, tooth and testis development. Homozygous knockout mice for this gene lack whiskers and exhibit tooth and palate defects, leading to neonatal lethality. [provided by RefSeq, Aug 2016]

Inhba Products (1)

mRNA Protein Name
NM_008380.2 NP_032406.1 inhibin beta A chain preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables signaling receptor binding IPI
IPI: Inferred from physical interaction
1646080 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within Sertoli cell differentiation IMP
IMP: Inferred from mutant phenotype
32274496 MGI
acts upstream of or within androgen metabolic process IMP
IMP: Inferred from mutant phenotype
32274496 MGI
acts upstream of or within androst-4-ene-3,17-dione biosynthetic process IMP
IMP: Inferred from mutant phenotype
32954300 MGI
involved in eyelid development in camera-type eye IGI
IGI: Inferred from genetic interaction
14551263 MGI
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
32274496 MGI
acts upstream of or within hematopoietic progenitor cell differentiation IDA
IDA: Inferred from direct assay
7799920 MGI
acts upstream of or within lipid metabolic process IMP
IMP: Inferred from mutant phenotype
32274496 MGI
acts upstream of or within male gonad development IMP
IMP: Inferred from mutant phenotype
32274496 MGI
acts upstream of or within mesoderm formation IDA
IDA: Inferred from direct assay
7799920 MGI
acts upstream of or within mesodermal cell differentiation IDA
IDA: Inferred from direct assay
7799920 MGI
involved in positive regulation of DNA-templated transcription IGI
IGI: Inferred from genetic interaction
14551263 MGI
involved in positive regulation of ovulation IMP
IMP: Inferred from mutant phenotype
17609433 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
10391928 MGI
acts upstream of or within steroid biosynthetic process IMP
IMP: Inferred from mutant phenotype
32954300 MGI
acts upstream of or within steroid metabolic process IMP
IMP: Inferred from mutant phenotype
32274496 MGI
acts upstream of or within testosterone biosynthetic process IMP
IMP: Inferred from mutant phenotype
32274496 MGI
acts upstream of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
10391928 MGI
Cellular Component GO Annotation Evidence References Source
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
8133077 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

inhibin beta A chain

  • activin A

  • activin beta-A chain

Recombinant Inhba Proteins

Cat. No. Product Name Accession Purity
HY-P73241 Activin A Protein, Human/Mouse/Rat (HEK293, His) Q3UY39/NP_032406.1 (S21-S424) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-124447 BTYNB 98.0% Unkown
HY-RS06813 INHBA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17466 Inhba Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23924 Inhba Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Inhba NCBI NCBI:3624