Acod1 - aconitate decarboxylase 1 Gene

Also Known as CAD; Irg1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16365

Summary

Enables aconitate decarboxylase activity. Involved in several processes, including cellular response to cytokine stimulus; negative regulation of defense response; and negative regulation of signal transduction. Acts upstream of or within response to lipopolysaccharide. Located in mitochondrion. Orthologous to human ACOD1 (aconitate decarboxylase 1). [provided by Alliance of Genome Resources, Apr 2022]

Acod1 Products (1)

mRNA Protein Name
NM_008392.1 NP_032418.1 cis-aconitate decarboxylase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables aconitate decarboxylase activity IDA
IDA: Inferred from direct assay
23610393 MGI
enables aconitate decarboxylase activity IMP
IMP: Inferred from mutant phenotype
30635240 MGI
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
31548418 MGI
Biological Process GO Annotation Evidence References Source
involved in cellular response to interferon-beta IDA
IDA: Inferred from direct assay
19014335 MGI
involved in cellular response to interleukin-1 IDA
IDA: Inferred from direct assay
19014335 MGI
involved in cellular response to lipopolysaccharide IDA
IDA: Inferred from direct assay
23609450 MGI
involved in cellular response to molecule of bacterial origin IDA
IDA: Inferred from direct assay
19014335 MGI
involved in cellular response to progesterone stimulus IDA
IDA: Inferred from direct assay
14500577 MGI
involved in cellular response to tumor necrosis factor IDA
IDA: Inferred from direct assay
19014335 MGI
involved in cellular response to type II interferon IDA
IDA: Inferred from direct assay
19014335 MGI
involved in defense response IDA
IDA: Inferred from direct assay
23610393 MGI
involved in defense response to virus IMP
IMP: Inferred from mutant phenotype
30635240 MGI
involved in embryo implantation IMP
IMP: Inferred from mutant phenotype
14500577 MGI
involved in negative regulation of NF-kappaB transcription factor activity IMP
IMP: Inferred from mutant phenotype
23609450 MGI
involved in negative regulation of inflammatory response IDA
IDA: Inferred from direct assay
23609450 MGI
involved in negative regulation of innate immune response IDA
IDA: Inferred from direct assay
23609450 MGI
involved in negative regulation of toll-like receptor 2 signaling pathway IMP
IMP: Inferred from mutant phenotype
23609450 MGI
involved in negative regulation of toll-like receptor 4 signaling pathway IDA
IDA: Inferred from direct assay
23609450 MGI
involved in negative regulation of type I interferon production IMP
IMP: Inferred from mutant phenotype
23609450 MGI
involved in positive regulation of antimicrobial humoral response IDA
IDA: Inferred from direct assay
23610393 MGI
involved in positive regulation of reactive oxygen species metabolic process IDA
IDA: Inferred from direct assay
23609450 MGI
acts upstream of or within response to bacterium IEP
IEP: Inferred from expression pattern
23012479 MGI
acts upstream of or within response to lipopolysaccharide IDA
IDA: Inferred from direct assay
7721348 MGI
involved in tolerance induction to lipopolysaccharide IDA
IDA: Inferred from direct assay
23609450 MGI
Cellular Component GO Annotation Evidence References Source
located in mitochondrion IDA
IDA: Inferred from direct assay
19014335 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cis-aconitate decarboxylase

  • cis-aconitic acid decarboxylase

  • immune-responsive gene 1 protein

  • immunoresponsive gene 1

Acod1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P84946 IRG1 Antibody (YA4642) WB, ICC/IF Mouse

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16239 Acod1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00172 ACOD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24527 Acod1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Acod1 NCBI NCBI:730249