Isl1 - ISL1 transcription factor, LIM/homeodomain Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16392

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; promoter-specific chromatin binding activity; and sequence-specific DNA binding activity. Involved in several processes, including heart development; nervous system development; and positive regulation of cytokine production. Acts upstream of or within several processes, including animal organ development; neuron development; and positive regulation of nitrogen compound metabolic process. Located in nucleus. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and heart and pericardium. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus and type 2 diabetes mellitus. Orthologous to human ISL1 (ISL LIM homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]

Isl1 Products (1)

mRNA Protein Name
NM_021459.4 NP_067434.3 insulin gene enhancer protein ISL-1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
19620969 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
15659653 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
18434421 MGI
enables promoter-specific chromatin binding IDA
IDA: Inferred from direct assay
24643061 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9192866 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
24643061 MGI
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
18539116 MGI
Biological Process GO Annotation Evidence References Source
involved in atrial septum morphogenesis IGI
IGI: Inferred from genetic interaction
17519333 MGI
acts upstream of canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
19620969 MGI
acts upstream of or within cardiac cell fate determination IMP
IMP: Inferred from mutant phenotype
19620969 MGI
acts upstream of or within cardiac muscle cell myoblast differentiation IMP
IMP: Inferred from mutant phenotype
19620969 MGI
involved in cardiac right ventricle morphogenesis IGI
IGI: Inferred from genetic interaction
17519333 MGI
acts upstream of cell population proliferation IDA
IDA: Inferred from direct assay
15659653 MGI
involved in endocardial cushion morphogenesis IGI
IGI: Inferred from genetic interaction
17519333 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
14667410 MGI
acts upstream of or within heart morphogenesis IGI
IGI: Inferred from genetic interaction
16687132 MGI
involved in innervation IMP
IMP: Inferred from mutant phenotype
18849985 MGI
acts upstream of or within mesenchymal cell differentiation IMP
IMP: Inferred from mutant phenotype
9000074 MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
19620969 MGI
involved in negative regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
22727192 MGI
involved in negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
18849985 MGI
acts upstream of or within negative regulation of neuron differentiation IGI
IGI: Inferred from genetic interaction
14766174 MGI
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
18849985 MGI
acts upstream of or within neural crest cell migration IGI
IGI: Inferred from genetic interaction
16687132 MGI
acts upstream of neuron differentiation IGI
IGI: Inferred from genetic interaction
14766174 MGI
acts upstream of or within neuron differentiation IGI
IGI: Inferred from genetic interaction
18434416 MGI
acts upstream of or within neuron differentiation IMP
IMP: Inferred from mutant phenotype
8565076 MGI
acts upstream of or within neuron fate commitment IGI
IGI: Inferred from genetic interaction
14766174 MGI
involved in neuron fate specification IMP
IMP: Inferred from mutant phenotype
18849985 MGI
involved in outflow tract morphogenesis IGI
IGI: Inferred from genetic interaction
17519333 MGI
involved in outflow tract septum morphogenesis IGI
IGI: Inferred from genetic interaction
17519333 MGI
acts upstream of or within pancreas development IMP
IMP: Inferred from mutant phenotype
9000074 MGI
involved in peripheral nervous system neuron axonogenesis IMP
IMP: Inferred from mutant phenotype
18849985 MGI
acts upstream of or within peripheral nervous system neuron development IGI
IGI: Inferred from genetic interaction
21734270 MGI
involved in pharyngeal system development IGI
IGI: Inferred from genetic interaction
17519333 MGI
acts upstream of or within pituitary gland development IMP
IMP: Inferred from mutant phenotype
9806931 MGI
acts upstream of or within positive regulation of DNA binding IDA
IDA: Inferred from direct assay
15659653 MGI
involved in positive regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
22727192 MGI
involved in positive regulation of cell differentiation IMP
IMP: Inferred from mutant phenotype
25775587 MGI
acts upstream of or within positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
15659653 MGI
involved in positive regulation of granulocyte colony-stimulating factor production IDA
IDA: Inferred from direct assay
22727192 MGI
involved in positive regulation of granulocyte macrophage colony-stimulating factor production IDA
IDA: Inferred from direct assay
22727192 MGI
involved in positive regulation of interleukin-1 alpha production IDA
IDA: Inferred from direct assay
22727192 MGI
involved in positive regulation of interleukin-1 beta production IDA
IDA: Inferred from direct assay
22727192 MGI
involved in positive regulation of interleukin-12 production IDA
IDA: Inferred from direct assay
22727192 MGI
involved in positive regulation of interleukin-6 production IDA
IDA: Inferred from direct assay
22727192 MGI
involved in positive regulation of macrophage colony-stimulating factor production IDA
IDA: Inferred from direct assay
22727192 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
19620969 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
18434421 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
14664703 MGI
involved in positive regulation of tumor necrosis factor production IDA
IDA: Inferred from direct assay
22727192 MGI
involved in positive regulation of type II interferon production IDA
IDA: Inferred from direct assay
22727192 MGI
acts upstream of or within positive regulation of tyrosine phosphorylation of STAT protein IDA
IDA: Inferred from direct assay
15659653 MGI
involved in positive regulation of vascular endothelial growth factor production IDA
IDA: Inferred from direct assay
22727192 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
19666821 MGI
acts upstream of regulation of heart rate by cardiac conduction IMP
IMP: Inferred from mutant phenotype
26193633 MGI
acts upstream of or within regulation of secondary heart field cardioblast proliferation IMP
IMP: Inferred from mutant phenotype
19620969 MGI
acts upstream of or within retinal ganglion cell axon guidance IMP
IMP: Inferred from mutant phenotype
18434421 MGI
involved in sensory system development IMP
IMP: Inferred from mutant phenotype
18849985 MGI
involved in sinoatrial node cell development IMP
IMP: Inferred from mutant phenotype
26193633 MGI
acts upstream of or within spinal cord motor neuron cell fate specification IGI
IGI: Inferred from genetic interaction
19666821 MGI
acts upstream of or within spinal cord motor neuron differentiation IMP
IMP: Inferred from mutant phenotype
8565076 MGI
acts upstream of or within stem cell differentiation IMP
IMP: Inferred from mutant phenotype
9000074 MGI
acts upstream of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
22343712 MGI
involved in trigeminal nerve development IMP
IMP: Inferred from mutant phenotype
18849985 MGI
involved in ventricular cardiac muscle tissue morphogenesis IGI
IGI: Inferred from genetic interaction
17519333 MGI
acts upstream of or within visceral motor neuron differentiation IGI
IGI: Inferred from genetic interaction
14766174 MGI
Cellular Component GO Annotation Evidence References Source
located in chromatin IDA
IDA: Inferred from direct assay
18539116 MGI
located in nucleus IDA
IDA: Inferred from direct assay
10536059 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

insulin gene enhancer protein ISL-1

  • Islet 1

  • Lim-homeodomain protein Islet1

  • insulin related protein

  • islet-1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06931 ISL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174594 Human ISL1 mRNA / Unkown
HY-RS18481 Isl1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24962 Isl1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Isl1 NCBI NCBI:3670