Itga2b - integrin alpha 2b Gene

Also Known as CD41; CD41B; GpIIb; alphaIIb

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16399

Summary

Enables extracellular matrix binding activity. Acts upstream of or within cell-matrix adhesion. Located in external side of plasma membrane and focal adhesion. Is expressed in several structures, including early conceptus; genitourinary system; gut; hematopoietic system; and liver. Used to study platelet-type bleeding disorder 16. Human ortholog(s) of this gene implicated in Glanzmann's thrombasthenia; platelet-type bleeding disorder 16; thrombocytopenia; and von Willebrand's disease 1. Orthologous to human ITGA2B (Integrin subunit alpha 2b). [provided by Alliance of Genome Resources, Apr 2022]

Itga2b Products (1)

mRNA Protein Name
NM_010575.2 NP_034705.2 integrin alpha-IIb precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables extracellular matrix binding IMP
IMP: Inferred from mutant phenotype
15031111 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cell-matrix adhesion IMP
IMP: Inferred from mutant phenotype
15031111 MGI
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
14751927 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
12900455 MGI
located in focal adhesion IDA
IDA: Inferred from direct assay
15031111 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

integrin alpha-IIb

  • GP IIb

  • GPalpha IIb

  • alpha IIb

  • platelet glycoprotein IIb of IIb/II Ia complex

  • platelet membrane glycoprotein IIb

Itga2b Antibodies

Cat. No. Product Name Application Reactivity
HY-P86806 CD41 Antibody (YA6499) IHC-P, FC, ICC/IF Mouse

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06949 ITGA2B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19782 Itga2b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26279 Itga2b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Itga2b NCBI NCBI:3674