Itgb1 - integrin beta 1 (fibronectin receptor beta) Gene

Also Known as CD29; Fnrb; gpIIa; Gm9863; 4633401G24Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16412

Summary

Enables Integrin binding activity. Contributes to laminin binding activity. Involved in several processes, including basement membrane organization; cellular response to low-density lipoprotein particle stimulus; and receptor internalization. Acts upstream of or within with a negative effect on reactive gliosis and regulation of spontaneous synaptic transmission. Acts upstream of or within several processes, including cell morphogenesis involved in differentiation; regulation of ion transmembrane transport; and striated muscle cell differentiation. Located in several cellular components, including Schaffer collateral - CA1 synapse; intercalated disc; and myelin sheath abaxonal region. Part of Integrin alpha7-beta1 complex. Is integral component of synaptic membrane. Colocalizes with cytoplasmic vesicle and perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and limb. Used to study Hirschsprung's disease. Orthologous to human ITGB1 (Integrin subunit beta 1). [provided by Alliance of Genome Resources, Apr 2022]

Itgb1 Products (1)

mRNA Protein Name
NM_010578.2 NP_034708.1 integrin beta-1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables integrin binding IPI
IPI: Inferred from physical interaction
1833411 MGI
enables integrin binding involved in cell-matrix adhesion IDA
IDA: Inferred from direct assay
22654117 MGI
contributes to laminin binding IDA
IDA: Inferred from direct assay
1839357 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10613898 MGI
enables signaling receptor activity IDA
IDA: Inferred from direct assay
36812915 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within G1/S transition of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
12957148 MGI
acts upstream of or within axon extension IGI
IGI: Inferred from genetic interaction
12879062 MGI
acts upstream of or within axon extension IMP
IMP: Inferred from mutant phenotype
12879062 MGI
involved in basement membrane organization IMP
IMP: Inferred from mutant phenotype
24681597 MGI
acts upstream of or within cardiac cell fate specification IMP
IMP: Inferred from mutant phenotype
9004034 MGI
acts upstream of or within cardiac muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
9004034 MGI
acts upstream of or within cardiac muscle cell myoblast differentiation IMP
IMP: Inferred from mutant phenotype
9004034 MGI
acts upstream of or within cell migration involved in sprouting angiogenesis IMP
IMP: Inferred from mutant phenotype
16424942 MGI
acts upstream of cell population proliferation IMP
IMP: Inferred from mutant phenotype
15056720 MGI
acts upstream of or within cell-matrix adhesion IGI
IGI: Inferred from genetic interaction
17099249 MGI
acts upstream of or within cell-matrix adhesion IMP
IMP: Inferred from mutant phenotype
21185282 MGI
involved in cellular response to low-density lipoprotein particle stimulus IDA
IDA: Inferred from direct assay
23395392 MGI
acts upstream of or within dendrite morphogenesis IGI
IGI: Inferred from genetic interaction
22357865 MGI
acts upstream of or within dendrite morphogenesis IMP
IMP: Inferred from mutant phenotype
22357865 MGI
acts upstream of or within formation of radial glial scaffolds IMP
IMP: Inferred from mutant phenotype
21185282 MGI
acts upstream of or within germ cell migration IMP
IMP: Inferred from mutant phenotype
10079228 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
7544313 MGI
involved in modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
17065460 MGI
involved in modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
17065460 MGI
acts upstream of or within myoblast fate specification IMP
IMP: Inferred from mutant phenotype
9004034 MGI
acts upstream of or within negative regulation of Rho protein signal transduction IGI
IGI: Inferred from genetic interaction
22357865 MGI
acts upstream of or within negative regulation of neuron differentiation IMP
IMP: Inferred from mutant phenotype
15056720 MGI
acts upstream of neuroblast proliferation IMP
IMP: Inferred from mutant phenotype
15056720 MGI
acts upstream of neuron differentiation IMP
IMP: Inferred from mutant phenotype
15056720 MGI
acts upstream of or within neuron projection development IMP
IMP: Inferred from mutant phenotype
19118221 MGI
acts upstream of or within positive regulation of glutamate uptake involved in transmission of nerve impulse IMP
IMP: Inferred from mutant phenotype
25716834 MGI
acts upstream of or within positive regulation of neuroblast proliferation IMP
IMP: Inferred from mutant phenotype
15056720 MGI
acts upstream of or within negative effect reactive gliosis IMP
IMP: Inferred from mutant phenotype
25716834 MGI
involved in receptor internalization IDA
IDA: Inferred from direct assay
23395392 MGI
acts upstream of or within regulation of cell cycle IMP
IMP: Inferred from mutant phenotype
14522949 MGI
acts upstream of or within regulation of inward rectifier potassium channel activity IMP
IMP: Inferred from mutant phenotype
25716834 MGI
acts upstream of or within negative effect regulation of spontaneous synaptic transmission IMP
IMP: Inferred from mutant phenotype
25716834 MGI
involved in regulation of synapse pruning IDA
IDA: Inferred from direct assay
24831527 MGI
involved in regulation of synapse pruning IMP
IMP: Inferred from mutant phenotype
24831527 MGI
involved in response to muscle activity IDA
IDA: Inferred from direct assay
36812915 MGI
acts upstream of or within sarcomere organization IMP
IMP: Inferred from mutant phenotype
9004034 MGI
NOT involved in stress fiber assembly IMP
IMP: Inferred from mutant phenotype
24036928 MGI
NOT involved in transforming growth factor beta receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
24036928 MGI
acts upstream of or within visual learning IGI
IGI: Inferred from genetic interaction
22357865 MGI
acts upstream of or within visual learning IMP
IMP: Inferred from mutant phenotype
22357865 MGI
Cellular Component GO Annotation Evidence References Source
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
17065460 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: Inferred from mutant phenotype
17065460 MGI
located in cell surface IDA
IDA: Inferred from direct assay
8306881 MGI
is active in cerebellar climbing fiber to Purkinje cell synapse IDA
IDA: Inferred from direct assay
24831527 MGI
is active in cerebellar climbing fiber to Purkinje cell synapse IMP
IMP: Inferred from mutant phenotype
24831527 MGI
colocalizes with cytoplasmic vesicle IDA
IDA: Inferred from direct assay
12189152 MGI
located in dendritic spine IDA
IDA: Inferred from direct assay
22357865 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
9553049 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
16467530 MGI
part of integrin alpha7-beta1 complex IDA
IDA: Inferred from direct assay
18611855 MGI
part of integrin alpha7-beta1 complex IPI
IPI: Inferred from physical interaction
1839357 MGI
part of integrin alpha9-beta1 complex IDA
IDA: Inferred from direct assay
22654117 MGI
located in intercalated disc IDA
IDA: Inferred from direct assay
11732910 MGI
located in membrane IDA
IDA: Inferred from direct assay
23395392 MGI
located in myelin sheath abaxonal region IDA
IDA: Inferred from direct assay
20237282 MGI
located in neuromuscular junction IDA
IDA: Inferred from direct assay
9415431 MGI
colocalizes with perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
12189152 MGI
colocalizes with plasma membrane IDA
IDA: Inferred from direct assay
12189152 MGI
is active in plasma membrane IDA
IDA: Inferred from direct assay
36812915 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
12591243 MGI
located in sarcolemma IDA
IDA: Inferred from direct assay
9415431 MGI
located in synapse IDA
IDA: Inferred from direct assay
12904471 MGI
is active in synaptic membrane IDA
IDA: Inferred from direct assay
16467530 MGI
located in synaptic membrane IDA
IDA: Inferred from direct assay
22357865 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

integrin beta-1

  • VLA-4 subunit beta

  • fibronectin receptor subunit beta

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P990643 OS-2966 Inhibitor 99.62% Phase 1

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06963 ITGB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16668 Itgb1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-E70297 N-Acetylglucosaminyltransferase IVa / Unkown
HY-RS06964 ITGB1BP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23103 Itgb1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992055 Anti-ITGB1 Antibody 96.16% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Itgb1 NCBI NCBI:3688