Itgb3 - integrin beta 3 Gene

Also Known as CD61; GP3A; INGRB3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16416

Summary

Enables Integrin binding activity and protein kinase C binding activity. Involved in several processes, including positive regulation of T cell migration; positive regulation of osteoblast proliferation; and regulation of serotonin uptake. Acts upstream of or within several processes, including cellular response to platelet-derived growth factor stimulus; positive regulation of cell-substrate adhesion; and positive regulation of fibroblast migration. Located in several cellular components, including external side of plasma membrane; focal adhesion; and glutamatergic synapse. Part of alpha9-beta1 integrin-ADAM8 complex and alphav-beta3 integrin-PKCalpha complex. Is integral component of synaptic membrane. Is expressed in several structures, including bladder; dorsal aorta; gut; liver; and lung. Used to study Glanzmann's thrombasthenia and platelet-type bleeding disorder 16. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; autoimmune thrombocytopenic purpura; blood platelet disease (multiple); end stage renal disease; and non-arteritic anterior ischemic optic neuropathy. Orthologous to human ITGB3 (Integrin subunit beta 3). [provided by Alliance of Genome Resources, Apr 2022]

Itgb3 Products (1)

mRNA Protein Name
NM_016780.2 NP_058060.2 integrin beta-3 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables enzyme binding IPI
IPI: Inferred from physical interaction
21670307 MGI
enables integrin binding IPI
IPI: Inferred from physical interaction
8601592 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12867986 MGI
enables protein kinase C binding IPI
IPI: Inferred from physical interaction
16014375 MGI
Biological Process GO Annotation Evidence References Source
involved in apoptotic cell clearance IGI
IGI: Inferred from genetic interaction
20826760 MGI
acts upstream of or within blood coagulation, fibrin clot formation IMP
IMP: Inferred from mutant phenotype
28576878 MGI
acts upstream of or within cell-matrix adhesion IGI
IGI: Inferred from genetic interaction
17099249 MGI
acts upstream of or within cell-substrate junction assembly IDA
IDA: Inferred from direct assay
12867986 MGI
acts upstream of or within cellular response to platelet-derived growth factor stimulus IMP
IMP: Inferred from mutant phenotype
22984613 MGI
acts upstream of or within platelet aggregation IMP
IMP: Inferred from mutant phenotype
28576878 MGI
acts upstream of or within platelet-derived growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
22984613 MGI
involved in positive regulation of T cell migration IDA
IDA: Inferred from direct assay
21670307 MGI
involved in positive regulation of cell migration IMP
IMP: Inferred from mutant phenotype
20675382 MGI
acts upstream of or within positive regulation of cell-matrix adhesion IMP
IMP: Inferred from mutant phenotype
22984613 MGI
acts upstream of or within positive regulation of fibroblast migration IMP
IMP: Inferred from mutant phenotype
22984613 MGI
acts upstream of or within positive regulation of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
22984613 MGI
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
25911094 MGI
involved in positive regulation of osteoblast proliferation IMP
IMP: Inferred from mutant phenotype
20675382 MGI
acts upstream of or within positive regulation of substrate adhesion-dependent cell spreading IMP
IMP: Inferred from mutant phenotype
22984613 MGI
involved in regulation of actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
25911094 MGI
acts upstream of or within regulation of extracellular matrix organization IMP
IMP: Inferred from mutant phenotype
22984613 MGI
involved in regulation of protein localization IMP
IMP: Inferred from mutant phenotype
29038237 MGI
acts upstream of or within regulation of protein tyrosine kinase activity IMP
IMP: Inferred from mutant phenotype
22984613 MGI
involved in regulation of serotonin uptake IMP
IMP: Inferred from mutant phenotype
29038237 MGI
acts upstream of or within regulation of trophoblast cell migration IMP
IMP: Inferred from mutant phenotype
15031111 MGI
Cellular Component GO Annotation Evidence References Source
part of alpha9-beta1 integrin-ADAM8 complex IDA
IDA: Inferred from direct assay
16995821 MGI
part of alphav-beta3 integrin-PKCalpha complex IDA
IDA: Inferred from direct assay
16014375 MGI
located in apical plasma membrane IDA
IDA: Inferred from direct assay
16216233 MGI
located in cell surface IDA
IDA: Inferred from direct assay
21670307 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
9553049 MGI
located in focal adhesion IDA
IDA: Inferred from direct assay
29038237 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
16467530 MGI
is active in glutamatergic synapse IEP
IEP: Inferred from expression pattern
16467530 MGI
located in synapse IDA
IDA: Inferred from direct assay
29038237 MGI
is active in synaptic membrane IDA
IDA: Inferred from direct assay
16467530 MGI
is active in synaptic membrane IEP
IEP: Inferred from expression pattern
16467530 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

integrin beta-3

  • GPIIIa

  • platelet glycoprotein IIIa (GP3A)

  • platelet gpIIIa

  • platelet membrane glycoprotein IIIa

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-175636 ITGB3-IN-1 Inhibitor 98.69% Unkown
HY-RS06966 ITGB3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18524 Itgb3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06967 ITGB3BP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25006 Itgb3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Itgb3 NCBI NCBI:3690