ITGB3 - integrin subunit beta 3 Gene

Also Known as GT; GT2; CD61; GP3A; BDPLT2; GPIIIa; BDPLT16; BDPLT24

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3690

About ITGB3

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:47,253,827-47,313,743 (from NCBI)

This gene has 4 transcripts (splice variants), 265 orthologues, 8 paralogues and is associated with 6 phenotypes. Broad expression in thyroid (RPKM 33.0), endometrium (RPKM 10.1) and 14 other tissues.

Summary

The ITGB3 protein product is the Integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. [provided by RefSeq, Jul 2008]

ITGB3 Products (1)

mRNA	Protein	Name
NM_000212.3	NP_000203.2	integrin beta-3 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
contributes to C-X3-C chemokine binding	IDA IDA: Inferred from direct assay	23125415	GOA
enables cell adhesion molecule binding	IPI IPI: Inferred from physical interaction	8837777	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	21670307	GOA
enables extracellular matrix binding	IDA IDA: Inferred from direct assay	22505472	GOA
contributes to fibroblast growth factor binding	IDA IDA: Inferred from direct assay	18441324	GOA
enables fibronectin binding	IMP IMP: Inferred from mutant phenotype	24658351	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	11606749	GOA
contributes to insulin-like growth factor I binding	IDA IDA: Inferred from direct assay	19578119	GOA
enables integrin binding	IPI IPI: Inferred from physical interaction	20826760	GOA
contributes to neuregulin binding	IDA IDA: Inferred from direct assay	20682778	GOA
enables protease binding	IDA IDA: Inferred from direct assay	22505472	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	1694173	GOA
enables protein disulfide isomerase activity	IDA IDA: Inferred from direct assay	12204115	GOA
enables vascular endothelial growth factor receptor 2 binding	IPI IPI: Inferred from physical interaction	10022831	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in activation of protein kinase activity	IMP IMP: Inferred from mutant phenotype	10022831	GOA
involved in apolipoprotein A-I-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	23726972	GOA
involved in apoptotic cell clearance	IGI IGI: Inferred from genetic interaction	20826760	GOA
involved in cell adhesion mediated by integrin	IDA IDA: Inferred from direct assay	12807887	GOA
involved in cell-matrix adhesion	IMP IMP: Inferred from mutant phenotype	7525578	GOA
involved in cell-substrate adhesion	IMP IMP: Inferred from mutant phenotype	19933311	GOA
involved in heterotypic cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	20563599	GOA
involved in mesodermal cell differentiation	IEP IEP: Inferred from expression pattern	23154389	GOA
involved in negative chemotaxis	IMP IMP: Inferred from mutant phenotype	23726972	GOA
involved in negative regulation of lipid storage	IMP IMP: Inferred from mutant phenotype	15215180	GOA
involved in negative regulation of lipid transport	IMP IMP: Inferred from mutant phenotype	15215180	GOA
involved in negative regulation of lipoprotein metabolic process	IMP IMP: Inferred from mutant phenotype	15215180	GOA
acts upstream of or within negative regulation of low-density lipoprotein receptor activity	IMP IMP: Inferred from mutant phenotype	15215180	GOA
involved in negative regulation of macrophage derived foam cell differentiation	IMP IMP: Inferred from mutant phenotype	15215180	GOA
involved in platelet activation	IMP IMP: Inferred from mutant phenotype	15466936	GOA
involved in platelet aggregation	IMP IMP: Inferred from mutant phenotype	15466936	GOA
involved in positive regulation of endothelial cell migration	IMP IMP: Inferred from mutant phenotype	10022831	GOA
involved in positive regulation of endothelial cell proliferation	IMP IMP: Inferred from mutant phenotype	10022831	GOA
involved in positive regulation of peptidyl-tyrosine phosphorylation	IMP IMP: Inferred from mutant phenotype	10022831	GOA
involved in regulation of postsynaptic neurotransmitter receptor internalization	EXP EXP: Inferred from Experiment	18549786	GOA
involved in regulation of postsynaptic neurotransmitter receptor internalization	IDA IDA: Inferred from direct assay	18549786	GOA
involved in regulation of postsynaptic neurotransmitter receptor internalization	IMP IMP: Inferred from mutant phenotype	18549786	GOA
involved in smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	8837777	GOA
involved in substrate adhesion-dependent cell spreading	IDA IDA: Inferred from direct assay	24658351	GOA
involved in symbiont entry into host cell	IMP IMP: Inferred from mutant phenotype	25063885	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of alphav-beta3 integrin-HMGB1 complex	IDA IDA: Inferred from direct assay	20826760	GOA
part of alphav-beta3 integrin-IGF-1-IGF1R complex	IDA IDA: Inferred from direct assay	19578119	GOA
part of alphav-beta3 integrin-PKCalpha complex	IDA IDA: Inferred from direct assay	16014375	GOA
located in cell surface	IDA IDA: Inferred from direct assay	7525578	GOA
located in cell-cell junction	IDA IDA: Inferred from direct assay	19461049	GOA
located in filopodium membrane	IDA IDA: Inferred from direct assay	25063885	GOA
located in focal adhesion	IDA IDA: Inferred from direct assay	23023225	GOA
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	18549786	GOA
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	18549786	GOA
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	18549786	GOA
part of integrin alphaIIb-beta3 complex	IPI IPI: Inferred from physical interaction	15378069	GOA
part of integrin alphav-beta3 complex	IDA IDA: Inferred from direct assay	20826760	GOA
part of integrin alphav-beta3 complex	IPI IPI: Inferred from physical interaction	11546839	GOA
part of integrin complex	IDA IDA: Inferred from direct assay	15215180	GOA
located in lamellipodium membrane	IDA IDA: Inferred from direct assay	25063885	GOA
located in melanosome	IDA IDA: Inferred from direct assay	15466936	GOA
located in microvillus membrane	IDA IDA: Inferred from direct assay	25063885	GOA
located in nucleus	IDA IDA: Inferred from direct assay	22027834	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	15466936	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	15344881	GOA
part of receptor complex	IDA IDA: Inferred from direct assay	23382219	GOA
located in ruffle membrane	IDA IDA: Inferred from direct assay	25063885	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ITGB3 Protein Structure

Integrin_beta

Integrin_B_tail

Integrin_b_cyt

0
200
400
600
788 a.a.

Protein Preferred Names	Protein Names
integrin beta-3	antigen CD61

ITGB3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ITGB3	P05106	Tln1	Mus musculus	P26039	NMR	21134644
Intra	ITGB3	P05106	Tln1	Mus musculus	P26039	NMR	17218263
Intra	ITGB3	P05106	CX3CL1	Homo sapiens	P78423	Anti Bait CoIP	23125415
Intra	ITGB3	P05106	ITGA2B	Homo sapiens	P08514-1	Pull Down	22178926
Intra	ITGB3	P05106	ITGA2B	Homo sapiens	P08514-1	Pull Down	25849143
Intra	ITGB3	P05106	ITGA2B	Homo sapiens	P08514-1	SPR	25849143
Intra	ITGB3	P05106	TLN1	Homo sapiens	Q9Y490	Affinity Techniques	16546176
Intra	ITGB3	P05106	TLN1	Homo sapiens	Q9Y490	FPS	35044719
Intra	ITGB3	P05106	TLN1	Homo sapiens	Q9Y490	Saturation Binding	16546176
Intra	ITGB3	P05106	ITGAV	Homo sapiens	P06756	X-Ray Diffraction	11884718
Intra	ITGB3	P05106	ITGAV	Homo sapiens	P06756	Pull Down	22178926
Intra	ITGB3	P05106	ITGAV	Homo sapiens	P06756	Solid Phase Assay	1694173
Intra	ITGB3	P05106	ITGAV	Homo sapiens	P06756	Anti Bait CoIP	20639902
Intra	ITGB3	P05106	FLNA	Homo sapiens	P21333	NMR	25849143
Intra	ITGB3	P05106	FLNA	Homo sapiens	P21333	SPR	25849143
Cross	ITGB3	P05106	Prkd1	Mus musculus	Q62101	ELISA	17485491
Intra	ITGB3	P05106	ITGA2B	Homo sapiens	P08514	TAP	19279667
Intra	ITGB3	P05106	ITGA2B	Homo sapiens	P08514	Lex-A Dimerization	14681217
Intra	ITGB3	P05106	PTPN1	Homo sapiens	P18031	Anti Bait CoIP	16115959
Cross	ITGB3	P05106	ACTN1	Gallus gallus	P05094	Solid Phase Assay	2116421
Cross	ITGB3	P05106	polg_wnv	West Nile virus	P06935	Anti Bait CoIP	16275649
Cross	ITGB3	P05106	polg_wnv	West Nile virus	P06935	3D-EM	16275649

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ITGB3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73868	Integrin alpha V beta 3 Protein, Human (HEK293, His, solution)	P06756-1 (F31-V992)&P05106-1 (G27-D718)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P77716	Integrin alpha 2B beta 3 Protein, Human (HEK293, His)	P08514 (L32-R993)&P05106 (G27-D718)	≥ 95%, as determined by reducing SDS-PAGE or Bis-Tris PAGE.
HY-P77719	Integrin alpha V beta 3 Protein, Human (HEK293, His-Avi)	P06756-1 (F31-V992)&P05106-1 (G27-D718)	≥ 95%, as determined by Bis-Tris PAGE.

ITGB3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80419	Integrin beta 3 Antibody (YA336)	WB, IHC-P, ICC/IF	Human, Mouse
HY-P83952	Integrin beta 3 Antibody (YA3649)	IHC-P, FC, ELISA	Human
HY-P83952A	Integrin beta 3 Antibody (YA3649)(PBS only)	IHC-P, FC, ELISA	Human
HY-P86412	Integrin beta 3 Antibody (YA6104)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Bleeding Disorder, Platelet-Type, 24	BDPLT24 Glanzmann Thrombasthenia-Like With Macrothrombocytopenia 2 Bleeding Disorder, Platelet-Type, 24, Autosomal Dominant
Glanzmann Thrombasthenia 2	GT2 Bleeding Disorder, Platelet-Type, 23 Bdplt23
Glanzmann Thrombasthenia 1	Glanzmann Thrombasthenia Thrombasthenia Of Glanzmann And Naegeli Glanzmann'S Thrombasthenia Bdplt2 Platelet Glycoprotein Iib-Iiia Deficiency Deficiency Of Platelet Fibrinogen Receptor GT1 Gt Platelet Fibrinogen Receptor Deficiency Glycoprotein Complex Iib-Iiia Deficiency Deficiency Of Glycoprotein Complex Iib-Iiia Glycoprotein Iib/Iiia Defect Glanzmann Thrombasthenia, Type A Thrombasthenia Bleeding Disorder, Platelet-Type, 2 Gp Iib-Iiia Complex Deficiency Deficiency Of Gp Iib-Iiia Complex Platelet-Type Bleeding Disorder 2 Thrombocytasthenia Deficiency Of Gp 2b 3a Complex Diacyclothrombopathia 2b 3a Glanzmann Thrombasthenia Type A Platelet Fibrinogen Receptor, Deficiency Of Platelet Glycoprotein 2b 3a Deficiency Glanzmann Disease Glanzmann-Naegeli Disorder Hereditary Hemorrhagic Thrombasthenia Hereditary Thrombasthenia Bleeding Disorder Platelet-Type 2
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Thrombasthenia
Bleeding Disorder, Platelet-Type, 16	Platelet-Type Bleeding Disorder 16 BDPLT16 Glanzmann Thrombasthenia-Like With Macrothrombocytopenia 1 Bleeding Disorder, Platelet-Type, 16, Autosomal Dominant Autosomal Dominant Glanzmann Thrombasthenia Autosomal Dominant Thrombasthenia Of Glanzmann And Naegeli Bleeding Disorder, Platelet Type 16 Glanzmann Thrombasthenia, Autosomal Dominant
Autosomal Dominant Macrothrombocytopenia
Coronary Thrombosis	Coronary Artery Thrombosis
Purpura	Purpuric Disorder
West Nile Virus	West Nile Virus, Susceptibility To Wnv Wnv, Susceptibility To West Nile Viral Infection Encephalitis, West Nile Fever West Nile Fever
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Fetal And Neonatal Alloimmune Thrombocytopenia	Nait Neonatal Alloimmune Thrombocytopenia Fnait
Heparin-Induced Thrombocytopenia	Hit Hat Heparin-Associated Thrombocytopenia Heparin-Induced Thrombocytopenia Type 2
Sclerosing Liposarcoma
Bernard-Soulier Syndrome	Giant Platelet Syndrome BSS Von Willebrand Factor Receptor Deficiency Bdplt1 Platelet Glycoprotein Ib Deficiency Bernard-Soulier Syndrome, Type A1 Bernard-Soulier Syndrome, Type B Bernard Soulier Syndrome Deficiency Of Platelet Glycoprotein 1b Hemorrhagiparous Thrombocytic Dystrophy Bernard-Soulier Syndrome Type C Bleeding Disorder, Platelet-Type, 1 Glycoprotein Ib, Platelet, Deficiency Of Giant Platelet Disorder, Isolated Giant Platelet Disease Macrothrombocytopenia, Familial Bernard-Soulier Type Bernard-Soulier Syndrome, Type C Bernard - Soulier Thrombopathy Hemorrhagic Dystrophic Thrombocytopenia Thrombopathy, Bernard-Soulier Platelet Glycoprotein 1b, Deficiency Of Hemorrhagioparous Thrombocytic Dystrophy Bernard-Soulier Syndrome Type A1 Bernard-Soulier Syndrome Type B Bleeding Disorder Platelet-Type 1 Gpd Macrothrombocytopenia, Familial, Bernard-Soulier Type
Thrombocytopenic Purpura, Autoimmune	Idiopathic Thrombocytopenic Purpura Autoimmune Thrombocytopenic Purpura Immune Thrombocytopenic Purpura Itp Idiopathic Purpura AITP Ideopath Thrombocytopenic Pur Primary Thrombocytopenic Purpura Werlhof'S Disease Thrombocytopenic Purpura Autoimmune Purpura Thrombocytopenic Idiopathic Purpura, Thrombocytopenic, Idiopathic Autoimmune Thrombocytopenia Thrombocytopenia Due To Platelet Alloimmunization Idiopathic Thrombocytopenia Idiopathic Thrombocytopenia Purpura Frank'S Essential Thrombocytopenia Itp - [Idiopathic Thrombocytopenia Purpura] Werlhof Disease Primary Autoimmune Thrombocytopenic Purpura Haemorrhagic Purpura Essential Thrombocytopenia Purpura Haemorrhagica
Erythroleukemia
Insulin-Like Growth Factor I	Insulin-Like Growth Factor I Deficiency IGF1 DEFICIENCY Insulin-Like Growth Factor I, Resistance To Growth Retardation With Deafness And Mental Retardation Due To Igf1 Deficiency Growth Delay Due To Insulin-Like Growth Factor Type 1 Deficiency Growth Delay Due To Insulin-Like Growth Factor I Resistance IGF1RES Igf-I Resistance Somatomedin, End-Organ Insensitivity To Somatomedin-C Somatomedin-C, Resistance To Growth Retardation With Sensorineural Deafness And Mental Retardation Insulin-Like Growth Factor 1 Resistance To Igf-1 Resistance Somatomedin End-Organ Insensitivity To Somatomedin-C Resistance To Growth Restriction With Sensorineural Deafness And Intellectual Disability Growth Delay-Deafness-Intellectual Disability Syndrome Growth Delay-Hearing Loss-Intellectual Disability Syndrome Igf-1 Deficiency Primary Insulin-Like Growth Factor Deficiency Resistance To Igf-1 Insulin-Like Growth Factor 1 Resistance End-Organ Insensitivity To Somatomedin Igf1 Resistance Resistance To Insulin-Like Growth Factor I Resistance To Somatomedin-C Insulin-Like Growth Factor 1, Resistance To
Thrombosis	Thrombosis Of Blood Vessel
Polycythemia Vera	PV Polycythemia Rubra Vera Prv Osler-Vaquez Disease Chronic Erythremia Polycythaemia Rubra Vera Primary Polycythemia Vaquez Disease Polycythemia Vera, Somatic Osler-Vaquez Syndrome Proliferative Polycythaemia Polycythemia Ruba Vera Acquired Primary Erythrocytosis Heilmeyer-Schoner Disease Vaquez Osler Disease Primary Polycythaemia
Adenomyosis	Endometriosis Of Uterus Endometriosis Interna Endometriosis Of Myometrium Endometriosis, Myometrium Uterine Adenomyosis Adenomyosis Uteri Internal Endometriosis
Polycythemia	Erythrocythemia Polycythemia Vera Polycythaemia Due To High Altitude
Thrombophilia	Hypercoagulability State
Osteopetrosis	Marble Bone Disease Albers-Schonberg Disease Osteopetroses Marble Bones Osteopetrosis And Related Disorders Congenital Osteopetrosis Marble Bone Albers-Schoenberg Disease Albers-Schonberg Osteopetrosis Osteosclerosis Fragilis Ivory Bones
Sarcoma	Connective And Soft Tissue Neoplasm Tumor Of Soft Tissue And Skeleton Sarcomas Sarcoma - Category
Primary Thrombocytopenia
Gastric Teratoma	Teratoma Of Stomach
Placental Insufficiency	Uteroplacental Vascular Insufficiency
Endocarditis
Thrombocytopenia Due To Platelet Alloimmunization	Immune Thrombocytopenia Autoimmune Thrombocytopenia Immune Thrombocytopenic Purpura Itp Auto-Immune Thrombocytopenia Thrombocytopenia Due To Immune Destruction Autoimmune Thrombocytopenic Purpura Idiopathic Thrombocytopenic Purpura Werlhof Disease
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Lipoprotein Quantitative Trait Locus	Coronary Artery Disease Coronary Artery Anomaly Coronary Artery Disease, Susceptibility To Myocardial Ischemia Congenital Anomaly Of Coronary Artery Coronary Arteriosclerosis Coronary Disease Coronary Heart Disease Coronary Artery Disorder LPAQTL Lpa Deficiency, Congenital Coronary Artery Abnormality Coronary Artery Anomaly, Congenital Chd Coronary Syndrome Congenital Malformations Of Coronary Vessels Malformation Of Coronary Vessels Congenital Coronary Artery Anomaly Congenital Coronary Artery Deformity Congenital Coronary Artery Disorder Abnormal Coronary Artery Congenital Coronary Artery Malposition Congenital Coronary Disease Congenital Anomaly Of Coronary Arteries
Acquired Thrombocytopenia	Secondary Thrombocytopenia
Bleeding Disorder, Platelet-Type, 18	Platelet-Type Bleeding Disorder 18 BDPLT18 Bleeding Disorder Due To Calcium- And Dag-Regulated Guanine Exchange Factor-1 Deficiency Bleeding Disorder Due To Caldag-Gefi Deficiency Bleeding Disorder, Platelet Type 18
Kaposi Sarcoma	Kaposi'S Sarcoma Kaposi Sarcoma, Susceptibility To Kaposi'S Sarcoma Of Lung Kaposi'S Sarcoma Of Palate Kaposi'S Sarcoma Of Soft Tissue Kaposi'S Sarcoma-Associated Herpesvirus Multiple Idiopathic Pigmented Hemangiosarcoma Multiple Idiopathic Pigmented Hemangiosarcoma, Susceptibility To African Lymphadenopathic Kaposi'S Sarcoma Anal Kaposi'S Sarcoma Cardiac Kaposi'S Sarcoma Central Nervous System Kaposi'S Sarcoma Conjunctival Kaposi'S Sarcoma Corneal Kaposi'S Sarcoma Cutaneous Kaposi'S Sarcoma Esophageal Kaposi'S Sarcoma Gallbladder Kaposi'S Sarcoma Gastric Kaposi'S Sarcoma Intestinal Kaposi'S Sarcoma Kaposi'S Sarcoma Of Anus Kaposi'S Sarcoma Of Central Nervous System Kaposi'S Sarcoma Of Conjunctiva Kaposi'S Sarcoma Of Cornea Kaposi'S Sarcoma Of Esophagus Kaposi'S Sarcoma Of Gastrointestinal Sites Kaposi'S Sarcoma Of Heart Kaposi'S Sarcoma Of Lymph Nodes Kaposi'S Sarcoma Of Penis Kaposi'S Sarcoma Of Skin Kaposi'S Sarcoma Of Soft Tissues Kaposi'S Sarcoma Of The Cns Kaposi'S Sarcoma Of The Gallbladder Kaposi'S Sarcoma Of The Prostate Kaposi'S Sarcoma, Lung Kaposi'S Sarcoma, Skin Lymph Node Kaposi'S Sarcoma Lymphadenopathic Kaposi'S Sarcoma Palate Kaposi'S Sarcoma Penis Kaposi'S Sarcoma Prostate Kaposi'S Sarcoma Pulmonary Kaposi'S Sarcoma Soft Tissue Kaposi'S Sarcoma Hhv8 Human Herpesvirus 8 Kshv Kaposi Sarcoma Herpesvirus Mediterranean Kaposi Sarcoma Non Aids Related Kaposi Sarcoma Sarcoma, Kaposi Sarcoma, Kaposi, Susceptibility To Non-Aids-Related Kaposi Sarcoma Angiolymphoid Hyperplasia Angiofollicular Ganglionic Hyperplasia Multi-Centric Castleman'S Disease
Arteriosclerosis	Arteriosclerotic Vascular Disease
Malignant Gastric Germ Cell Tumor	Germ Cell Tumor Of The Stomach Germ Cell Tumour Of The Stomach Malignant Gastric Germ Cell Tumour
Myelitis	Spinal Cord Inflammation Nos Radiculomyelitis Nos Myeloradiculitis
Myeloproliferative Neoplasm	Myeloproliferative Disorder Chronic Myeloproliferative Disease Myeloproliferative Neoplasms Chronic Myeloproliferative Disorder Cmpd Cmpd, U Chronic Myeloproliferative Disorders Mpd Mpn Myeloproliferative Disorders Myeloproliferative Disease Campomelic Dysplasia
Blood Coagulation Disease	Blood Coagulation Disorders Coagulation Protein Disease Inherited Blood Coagulation Disease Postpartum Coagulation Defect Postpartum Coagulation Defect With Delivery Coagulation Protein Disorders Puerperal Coagulopathy
Myeloproliferative Syndrome, Transient	Transient Abnormal Myelopoiesis Transient Myeloproliferative Syndrome Transient Myeloproliferative Disease Mst Tam Leukemia, Transient, Of Down Syndrome Tmd Leukemia, Transient Transient Leukemia Transient Leukemia Of Down Syndrome
Blood Platelet Disease	Platelet Disorder Blood Platelet Disorders Thrombocytopathy Platelet Dysfunction Platelet Disorders Qualitative Platelet Deficiency
Focal Segmental Glomerulosclerosis	Familial Idiopathic Steroid-Resistant Nephrotic Syndrome Focal Glomerulosclerosis Fsgs Segmental Glomerulosclerosis Glomerulosclerosis, Focal Segmental Fgs Focal Glomerular Sclerosis Familial Idiopathic Nephrotic Syndrome Focal Sclerosis With Hyalinosis Glomerulosclerosis, Focal Glomerulosclerosis Focal Glomerulosclerosis, Segmental, Focal Focal Segmental Glomerulosclerosis, Not Otherwise Specified
Infertility
Acute Megakaryocytic Leukemia	Acute Megakaryoblastic Leukemia Acute Megakaryoblastic Leukaemia Megakaryocytic Myelosis Thrombocytic Leukaemia Amkl Aml M7 Acute Myeloblastic Leukemia Type 7 Acute Myeloid Leukemia M7 Megakaryoblastic Leukemia Acute Leukemia, Megakaryoblastic, Acute Acute Myeloid Leukaemia, M7 Acute Megakaryocytic Leukaemia Acute Megakaryoblastic Leukaemia, Fab M7 Fab M7 Malignant Megakaryocytosis M7 - Acute Megakaryoblastic Leukaemia Megakaryoblastic Leukaemia Megakaryocytic Leukaemia Acute Megakaryoblastic Leukaemia, Nos Acute Megakaryoblastic Leukaemia Without Mention Of Remission
Fallopian Tube Clear Cell Adenocarcinoma	Clear Cell Carcinoma Of The Fallopian Tube
Marfan Syndrome	MFS Mfs1 Marfan'S Syndrome Marfan Syndrome Type 1 Marfan Syndrome, Type I Mass Phenotype Contractural Arachnodactyly Mass Syndrome Octd Overlap Connective Tissue Disease Marfanoid Hypermobility Syndrome Marfan Disease
Ciliary Dyskinesia, Primary, 1	CILD1 Pcd Primary Ciliary Dyskinesia 1 Kartagener Syndrome Ciliary Dyskinesia, Primary, 1, With Or Without Situs Inversus Immotile Cilia Syndrome Ics Polynesian Bronchiectasis Primary Ciliary Dyskinesia 1 With Or Without Situs Inversus Ics1 Immotile Cilia Syndrome 1 Primary Ciliary Dyskinesia KTGS Dextrocardia-Bronchiectasis-Sinusitis Syndrome Immotile Cilia Syndrome Kartagener Type Primary Ciliary Dyskinesia Kartagener Type Siewert Syndrome Immotile Cilia Dyskinesia, Ciliary, Primary, Type 1 Ciliary Motility Disorders
Mucocele Of Appendix	Appendicele Mucocele Appendicular Mucocele Appendiceal Mucocele
Arrhythmogenic Right Ventricular Cardiomyopathy	Arrhythmogenic Right Ventricular Dysplasia Arvc Arvd Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy Arvc Cardiomyopathy Arrhythmogenic Right Ventricular Cardiomyopathy-Dysplasia Arvd/C Right Ventricular Dysplasia, Arrhythmogenic Ventricular Dysplasia, Right, Arrhythmogenic Cardiomyopathy, Ventricular, Right, Arrhythmogenic Dysplasia, Arrhythmogenic Right Ventricular
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Essential Thrombocythemia	Essential Thrombocytosis Familial Thrombocytosis Hemorrhagic Thrombocythemia Hereditary Thrombocythemia Primary Thrombocytosis Idiopathic Thrombocythemia Primary Thrombocythemia Thrombocythemia, Essential Essential Thrombocythaemia Et Familial Thrombocythemia Thrombocythemia Essential
Cerebral Palsy	Infantile Cerebral Palsy Mixed Cerebral Palsy Palsy Cerebral Palsy, Cerebral Cerebral Palsy, Mixed
Appendix Lymphoma	Appendiceal Lymphoma
Leukemia, Chronic Myeloid	Chronic Myeloid Leukemia Chronic Myelogenous Leukemia CML Chronic Granulocytic Leukemia Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib Chronic Myeloid Leukaemia Chronic Granulocytic Leukaemia Chronic Myelogenous Leukaemia Myeloid Leukemia, Chronic Leukemia, Chronic Myelogenous Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic Cml - Chronic Myelogenous Leukemia Cgl Chronic Myelocytic Leukemia Leukemia, Chronic Myeloid, Atypical ACML Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative Myeloid Leukemia Chronic Leukemia, Myeloid, Chronic Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative Cml- [Chronic Myeloid Leukaemia] Cgl - [Chronic Granulocytic Leukaemia] Chronic Myelocytic Leukaemia
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-175636	ITGB3-IN-1	Inhibitor	98.69%	Unkown
HY-RS06966	ITGB3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18524	Itgb3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06967	ITGB3BP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25006	Itgb3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ITGB3	MGD	MGI:96612
Rattus norvegicus	ITGB3	RGD	RGD:628868
Macaca mulatta	ITGB3	VGNC	VGNC:104624