DNAJB8 - DnaJ heat shock protein family (Hsp40) member B8 Gene

Also Known as DJ6; CT156

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 165721

About DNAJB8

Cytogenetic location: 3q21.3 Genomic coordinates (GRCh38): 3:128,462,437-128,466,890 (from NCBI)

This gene has 2 transcripts (splice variants), 412 orthologues and 11 paralogues. Restricted expression toward testis (RPKM 16.6).

Summary

The protein encoded by this gene belongs to the DNAJ/HSP40 family of proteins that regulate chaperone activity. This family member suppresses aggregation and toxicity of polyglutamine proteins, and the C-terminal tail is essential for this activity. It has been implicated as a cancer-testis antigen and as a Cancer stem-like cell antigen involved in renal cell carcinoma. [provided by RefSeq, Jun 2012]

DNAJB8 Products (1)

mRNA Protein Name
NM_153330.6 NP_699161.1 dnaJ homolog subfamily B member 8

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein folding chaperone IDA
IDA: Inferred from direct assay
23612975 GOA
enables protein-folding chaperone binding IPI
IPI: Inferred from physical interaction
21231916 GOA
enables unfolded protein binding IDA
IDA: Inferred from direct assay
21231916 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within chaperone-mediated protein folding IDA
IDA: Inferred from direct assay
23612975 GOA
involved in negative regulation of inclusion body assembly IDA
IDA: Inferred from direct assay
21231916 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
21231916 GOA
located in nucleus IDA
IDA: Inferred from direct assay
21231916 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DNAJB8 Protein Structure

DnaJ

DnaJ: DnaJ domain (3 - 66)

  • 0
  • 100
  • 200
  • 232 a.a.
Protein Preferred Names Protein Names

dnaJ homolog subfamily B member 8

  • DnaJ (Hsp40) homolog, subfamily B, member 8

Related Diseases

Diseases Alias
Fatal Infantile Hypertonic Myofibrillar Myopathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03870 DNAJB8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus DNAJB8 RGD RGD:1561981
Canis familiaris DNAJB8 VGNC VGNC:54595
Felis catus DNAJB8 VGNC VGNC:78442
Mus musculus DNAJB8 MGD MGI:1922801
Others DNAJB8 NCBI