Lamb1 - laminin B1 Gene

Also Known as Lamb-1; Lamb1-1; D130003D08Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16777

Summary

Enables enzyme binding activity; glycosphingolipid binding activity; and Integrin binding activity. Involved in negative regulation of cell adhesion. Acts upstream of or within cell migration; embryo implantation; and neuron projection development. Located in basement membrane; nucleus; and perinuclear region of cytoplasm. Part of laminin-1 complex and laminin-10 complex. Is expressed in several structures, including alimentary system; extraembryonic component; eye; genitourinary system; and nervous system. Human ortholog(s) of this gene implicated in autistic disorder and lissencephaly 5. Orthologous to human LAMB1 (laminin subunit beta 1). [provided by Alliance of Genome Resources, Apr 2022]

Lamb1 Products (1)

mRNA Protein Name
NM_008482.3 NP_032508.3 laminin subunit beta-1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables enzyme binding IPI
IPI: Inferred from physical interaction
15474030 MGI
enables glycosphingolipid binding IDA
IDA: Inferred from direct assay
19118221 MGI
enables integrin binding IMP
IMP: Inferred from mutant phenotype
9004048 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
7639691 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cell migration IMP
IMP: Inferred from mutant phenotype
9004048 MGI
acts upstream of or within embryo implantation IMP
IMP: Inferred from mutant phenotype
15102706 MGI
involved in negative regulation of cell adhesion IDA
IDA: Inferred from direct assay
7639691 MGI
acts upstream of or within neuron projection development IDA
IDA: Inferred from direct assay
19118221 MGI
Cellular Component GO Annotation Evidence References Source
located in basement membrane IDA
IDA: Inferred from direct assay
1292752 MGI
located in extracellular matrix IDA
IDA: Inferred from direct assay
16554364 MGI
part of laminin complex IDA
IDA: Inferred from direct assay
8034675 MGI
part of laminin-1 complex IDA
IDA: Inferred from direct assay
9264260 MGI
part of laminin-10 complex IPI
IPI: Inferred from physical interaction
9299121 MGI
located in nucleus IDA
IDA: Inferred from direct assay
10444590 MGI
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
15207330 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

laminin subunit beta-1

  • laminin B1 chain

  • laminin B1 subunit 1

  • laminin-1 subunit beta

  • laminin-10 subunit beta

  • laminin-111

  • laminin-12 subunit beta

  • laminin-2 subunit beta

  • laminin-6 subunit beta

  • laminin-8 subunit beta

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-182561 Cgs 27830 Antagonist / Unkown
HY-N1045 13-Keto-8(14)-Podocarpen-18-oic acid / Unkown
HY-N1607 18-Nor-4,15-dihydroxyabieta-8,11,13-trien-7-one / Unkown
HY-RS07502 LAMB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-N3766 Diosbulbin G / Unkown
HY-N4013 Imbricatoloic acid / Unkown
HY-RS21624 Lamb1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28142 Lamb1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lamb1 NCBI NCBI:3912