Lcp2 - lymphocyte cytosolic protein 2 Gene

Also Known as twm; SLP76; SLP-76; m1Khoe

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16822

Summary

Acts upstream of or within mast cell activation. Located in cell-cell junction. Is expressed in thymus primordium. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human LCP2 (lymphocyte cytosolic protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Lcp2 Products (1)

mRNA Protein Name
NM_010696.4 NP_034826.2 lymphocyte cytosolic protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15477347 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cytokine production IMP
IMP: Inferred from mutant phenotype
15153494 MGI
acts upstream of or within mast cell activation IMP
IMP: Inferred from mutant phenotype
15153494 MGI
Cellular Component GO Annotation Evidence References Source
located in cell-cell junction IDA
IDA: Inferred from direct assay
23793062 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lymphocyte cytosolic protein 2

  • SH2 domain-containing leukocyte protein of 76 kDa

  • SLP-76 tyrosine phosphoprotein

Lcp2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Lcp2 Q60787 Cd6 Mus musculus Q61003
Affinity Chrom
24584089
Intra
Lcp2 Q60787 Cd6 Mus musculus Q61003
Anti Bait CoIP
24584089
Intra
Lcp2 Q60787 Lat Mus musculus O54957
Affinity Chrom
24584089
Intra
Lcp2 Q60787 Grap2 Mus musculus O89100
Affinity Chrom
24584089
Intra
Lcp2 Q60787 Fyb1 Mus musculus O35601
Affinity Chrom
24584089
Intra
Lcp2 Q60787 Fyb1 Mus musculus O35601
Pull Down
15477347
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07564 LCP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20761 Lcp2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27275 Lcp2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lcp2 NCBI NCBI:3937