Fyb - FYN binding protein Gene

Also Known as ADAP; Fyb1; Slap130; p120/130; p120/p130; FYB-120/130; B630013F22Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 23880

Summary

The protein encoded by this gene is an adapter molecule that affects T cell receptor signaling and contains multiple protein-protein interaction domains. It is thought to couple T cell receptor stimulation with activation of Integrin function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]

Fyb Products (2)

mRNA Protein Name
NM_001278269.1 NP_001265198.1 FYN-binding protein 1 isoform 2
NM_011815.5 NP_035945.1 FYN-binding protein 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12681493 MGI
Biological Process GO Annotation Evidence References Source
NOT acts upstream of or within mast cell activation IMP
IMP: Inferred from mutant phenotype
15153494 MGI
acts upstream of or within protein localization to plasma membrane IMP
IMP: Inferred from mutant phenotype
17403904 MGI
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
17403904 MGI
part of protein-containing complex IDA
IDA: Inferred from direct assay
12681493 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

FYN-binding protein 1

  • FYN binding protein FYB-130

  • FYN-T-binding protein

  • SLP-76-associated phosphoprotein

  • adhesion and degranulation promoting adaptor protein

Fyb Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Fyb1 O35601 Lcp2 Mus musculus Q60787
Pull Down
15477347
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05172 FYB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown