Lifr - LIF receptor alpha Gene

Also Known as LIF; A230075M04Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16880

Summary

Predicted to enable several functions, including ciliary neurotrophic factor receptor binding activity; growth factor binding activity; and Leukemia Inhibitory Factor receptor activity. Predicted to contribute to ciliary neurotrophic factor receptor activity and oncostatin-M receptor activity. Acts upstream of or within positive regulation of cell population proliferation. Predicted to be located in extracellular region and plasma membrane. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and immune system. Used to study CAKUT. Human ortholog(s) of this gene implicated in osteochondrodysplasia. Orthologous to human LIFR (LIF receptor subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]

Lifr Products (3)

mRNA Protein Name
NM_001113386.1 NP_001106857.1 leukemia inhibitory factor receptor isoform 2 precursor
NM_001358593.1 NP_001345522.1 leukemia inhibitory factor receptor isoform 1 precursor
NM_013584.2 NP_038612.1 leukemia inhibitory factor receptor isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15051883 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within positive regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
15051883 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

leukemia inhibitory factor receptor

  • D-factor/LIF receptor

  • LIF-R

  • leukemia inhibitory factor receptor alpha chain

  • soluble differentiation-stimulating factor receptor

Recombinant Lifr Proteins

Cat. No. Product Name Accession Purity
HY-P77061 LIFR Protein, Mouse (HEK293, His) P42703/NP_038612.1 (L44-S828) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-120142 EC359 Inducer 99.77% Unkown
HY-169192 BAR-2227 Agonist / Unkown
HY-178477 LIFR/GPBAR1 modulator 1 / Unkown
HY-RS07641 LIFR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17192 Lifr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23643 Lifr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lifr NCBI NCBI:3977