Loxl3 - lysyl oxidase-like 3 Gene

Also Known as Lor2; Loxl2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16950

Summary

Enables fibronectin binding activity and protein-lysine 6-oxidase activity. Involved in several processes, including fibronectin fibril organization; negative regulation of T-helper 17 cell lineage commitment; and peptidyl-lysine oxidation. Located in extracellular space. Is expressed in several structures, including alimentary system; connective tissue; limb mesenchyme; sensory organ; and skeleton. Orthologous to human LOXL3 (Lysyl Oxidase like 3). [provided by Alliance of Genome Resources, Apr 2022]

Loxl3 Products (1)

mRNA Protein Name
NM_013586.5 NP_038614.2 lysyl oxidase homolog 3 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables fibronectin binding IDA
IDA: Inferred from direct assay
26954549 MGI
enables protein-lysine 6-oxidase activity IDA
IDA: Inferred from direct assay
26954549 MGI
Biological Process GO Annotation Evidence References Source
involved in fibronectin fibril organization IMP
IMP: Inferred from mutant phenotype
26954549 MGI
involved in inflammatory response IMP
IMP: Inferred from mutant phenotype
28065600 MGI
involved in lung development IMP
IMP: Inferred from mutant phenotype
27645581 MGI
involved in negative regulation of T-helper 17 cell lineage commitment IMP
IMP: Inferred from mutant phenotype
28065600 MGI
involved in peptidyl-lysine oxidation IDA
IDA: Inferred from direct assay
26954549 MGI
involved in positive regulation of integrin-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
26954549 MGI
involved in roof of mouth development IMP
IMP: Inferred from mutant phenotype
26307084 MGI
involved in somite development IMP
IMP: Inferred from mutant phenotype
26954549 MGI
involved in spinal cord development IMP
IMP: Inferred from mutant phenotype
26307084 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
26954549 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lysyl oxidase homolog 3

  • lysyl oxidase-like 2

  • lysyl oxidase-like protein 3

  • lysyl oxidase-related protein 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-114286A PXS-5153A monohydrochloride Inhibitor 99.59% Unkown
HY-170538 SNT-5382 Inhibitor 99.96% Unkown
HY-151499A PXS-6302 hydrochloride Inhibitor 99.57% Unkown
HY-151498A PXS-4787 hydrochloride Inhibitor 99.71% Unkown
HY-114286 PXS-5153A Inhibitor / Unkown
HY-151498 PXS-4787 Inhibitor / Unkown
HY-151499 PXS-6302 Inhibitor / Unkown
HY-180581 LOXL2/sGC modulator-1 / Unkown
HY-RS07743 LOXL3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21632 Loxl3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28150 Loxl3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Loxl3 NCBI NCBI:84695