Prkcd - protein kinase C, delta Gene

Also Known as Pkcd

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 170538

About Prkcd

Primary_assembly 16: 5,769,215-5,799,352 reverse strand.mRatBN7.2:CM026989.1

This gene has 3 transcripts (splice variants), 289 orthologues, 5 paralogues and is associated with 27 phenotypes. Biased expression in Lung (RPKM 21.4), Spleen (RPKM 28.8) and 9 other tissues.

Summary

Enables TIR domain binding activity; calcium-independent protein kinase C activity; and protein kinase binding activity. Involved in several processes, including D-aspartate import across plasma membrane; positive regulation of MAP kinase activity; and positive regulation of glucose import. Located in several cellular components, including cytosol; mitochondrion; and nucleus. Is active in postsynaptic cytosol. Used to study brain ischemia and hypertension. Biomarker of hyperinsulinism; hypertension; muscular disease; obesity; and restrictive cardiomyopathy. Human ortholog(s) of this gene implicated in autoimmune lymphoproliferative syndrome type 3 and fatty liver disease. Orthologous to human PRKCD (protein kinase C delta). [provided by Alliance of Genome Resources, Apr 2022]

Prkcd Products (1)

mRNA Protein Name
NM_133307.2 NP_579841.2 protein kinase C delta type

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables TIR domain binding IPI
IPI: Inferred from physical interaction
17161867 RGD
enables diacylglycerol-dependent serine/threonine kinase activity EXP
EXP: Inferred from Experiment
12198130 RGD
enables diacylglycerol-dependent, calcium-independent serine/threonine kinase activity IDA
IDA: Inferred from direct assay
1915352 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
9514928 RGD
enables protein kinase binding IPI
IPI: Inferred from physical interaction
15337529 RGD
Biological Process GO Annotation Evidence References Source
involved in D-aspartate import across plasma membrane IMP
IMP: Inferred from mutant phenotype
17364745 RGD
involved in apoptotic process IMP
IMP: Inferred from mutant phenotype
21696630 RGD
involved in cellular response to glucose starvation IEP
IEP: Inferred from expression pattern
17728702 RGD
involved in cellular response to insulin stimulus IEP
IEP: Inferred from expression pattern
17046201 RGD
involved in cellular response to oxidative stress IDA
IDA: Inferred from direct assay
21696630 RGD
involved in collagen metabolic process IMP
IMP: Inferred from mutant phenotype
17728702 RGD
involved in intracellular signal transduction IDA
IDA: Inferred from direct assay
11562372 RGD
involved in positive regulation of D-glucose import IMP
IMP: Inferred from mutant phenotype
17098211 RGD
involved in positive regulation of MAP kinase activity IMP
IMP: Inferred from mutant phenotype
16935468 RGD
involved in positive regulation of MAPK cascade IMP
IMP: Inferred from mutant phenotype
12790799 RGD
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
12663471 RGD
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
10085132 RGD
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
1915352 RGD
involved in regulation of phosphorylation IDA
IDA: Inferred from direct assay
21696630 RGD
involved in response to amino acid IEP
IEP: Inferred from expression pattern
17210758 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
17728104 RGD
involved in response to glucose IEP
IEP: Inferred from expression pattern
12960081 RGD
involved in response to hydrogen peroxide IEP
IEP: Inferred from expression pattern
12226102 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
16936002 RGD
involved in response to mechanical stimulus IEP
IEP: Inferred from expression pattern
17487266 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
11478406 RGD
involved in response to oxidative stress IMP
IMP: Inferred from mutant phenotype
11576956 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
17123493 RGD
Cellular Component GO Annotation Evidence References Source
is active in postsynaptic cytosol IDA
IDA: Inferred from direct assay
8263228 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Prkcd Protein Structure

C1_nPKC_theta-like_rpt1

C1_nPKC_theta-like_rpt1: cd20834 (151 - 211)

C1_nPKC_theta-like_rpt2

C1_nPKC_theta-like_rpt2: cd20837 (230 - 279)

PKc_like

PKc_like: cl21453 (350 - 665)

  • 0
  • 200
  • 400
  • 600
  • 673 a.a.
Protein Preferred Names Protein Names

protein kinase C delta type

  • nPKC-delta

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11122 PRKCD Human Pre-designed siRNA Set A / Unkown
HY-RS11123 Prkcd Mouse Pre-designed siRNA Set A / Unkown
HY-RS11124 Prkcd Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Prkcd NCBI NCBI:5580