Fgf23 - fibroblast growth factor 23 Gene

Also Known as Fgf8b

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 170583

Summary

Predicted to enable growth factor activity and type 1 Fibroblast Growth Factor receptor binding activity. Involved in several processes, including cellular response to hormone stimulus; cellular response to interleukin-6; and cellular response to vitamin D. Located in extracellular space. Biomarker of chronic kidney disease and uremia. Human ortholog(s) of this gene implicated in autosomal dominant hypophosphatemic rickets. Orthologous to human FGF23 (Fibroblast Growth Factor 23). [provided by Alliance of Genome Resources, Apr 2022]

Fgf23 Products (1)

mRNA Protein Name
NM_130754.2 NP_570110.1 fibroblast growth factor 23 precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in cellular response to interleukin-6 IEP
IEP: Inferred from expression pattern
23263654 RGD
involved in cellular response to leptin stimulus IEP
IEP: Inferred from expression pattern
23263654 RGD
involved in cellular response to parathyroid hormone stimulus IEP
IEP: Inferred from expression pattern
20685823 RGD
involved in cellular response to vitamin D IEP
IEP: Inferred from expression pattern
23263654 RGD
involved in negative regulation of hormone secretion IDA
IDA: Inferred from direct assay
17992255 RGD
involved in response to magnesium ion IEP
IEP: Inferred from expression pattern
23608165 RGD
involved in response to sodium phosphate IEP
IEP: Inferred from expression pattern
24625659 RGD
involved in vitamin D metabolic process IEP
IEP: Inferred from expression pattern
15531762 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
15531762 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

fibroblast growth factor 23

  • FGF-23

  • fibroblast growth factor 8b

Recombinant Fgf23 Proteins

Cat. No. Product Name Accession Purity
HY-P72195 FGF-23 Protein, Rat (His) Q8VI82 (Y25-V251) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P700493 FGF-23 Protein, Rat (P. pastoris, His) Q8VI82 (Y25-V251) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N1428C Ferric citrate Activator / Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-159978 EOS789 Inhibitor 99.14% Phase 1

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-125961 T3Inh-1 Inhibitor 99.93% Unkown
HY-150687 ZINC12409120 Inhibitor 99.95% Unkown
HY-173191 SK-124 Inhibitor 95.0% Unkown
HY-186173 MD-3-A45 Inhibitor 99.9% Unkown
HY-183371 ZINC13407541 Antagonist / Unkown
HY-RS04900 FGF23 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W012856 3-Ethyltoluene / Unkown
HY-174698 Human FGF23 mRNA / Unkown
HY-RS16734 Fgf23 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23171 Fgf23 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fgf23 NCBI NCBI:8074