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Cat. No.: HY-183371

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ZINC13407541

ZINC13407541 is a fibroblast growth factor 23 (FGF23) antagonist with an IC₅₀ of 0.45 μM. ZINC13407541 preferentially binds to the FGF23:FGFR interface to disrupt their protein-protein interactions. ZINC13407541 can be used for the research of hypophosphatemia.

For research use only. We do not sell to patients.

CAS No.: 864868-22-4
Formula: C₁₄H₁₅NO
Molecular Weight:213.28

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

ZINC13407541 Chemical Structure

CAS No.: 864868-22-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HEK-293T	EC₅₀	1.41 10^3 μM Compound: 1; ZINC13407541	Cytotoxicity against HEK293T cells assessed as effect on LDH release measured after 5 hrs by CytoTox96 Non-Radioactive assay Cytotoxicity against HEK293T cells assessed as effect on LDH release measured after 5 hrs by CytoTox96 Non-Radioactive assay	[PMID: 33232874]

In Vitro

ZINC13407541 acts as an FGF23 antagonist with an IC₅₀ of 0.45 μM^[1].
ZINC13407541 can bind to the non-FGFR-interacting distal pocket of FGF23_Nterm, but also reveals it can bind to the predicted FGF23:FGFR protein-protein interaction region^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 864868-22-4
Molecular Weight 213.28
Formula C₁₄H₁₅NO
SMILES

O/N=C/C1=C(CCC1)/C=C/C2=CC=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Velazquez HA, et al. Ensemble docking to difficult targets in early-stage drug discovery: Methodology and application to fibroblast growth factor 23. Chem Biol Drug Des. 2018;91(2):491-504. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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