Map4k3 - mitogen-activated protein kinase kinase kinase kinase 3 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 170920

About Map4k3

Primary_assembly 6: 14,277,121-14,446,334 forward strand.mRatBN7.2:CM026979.1

This gene has 6 transcripts (splice variants), 211 orthologues, 36 paralogues and is associated with 4 phenotypes. Biased expression in Kidney (RPKM 225.), Lung (RPKM 194.) and 9 other tissues.

Summary

Enables SH3 domain binding activity. Predicted to be involved in several processes, including protein phosphorylation; response to UV; and response to tumor necrosis factor. Orthologous to human MAP4K3 (mitogen-activated protein kinase kinase kinase kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Map4k3 Products (1)

mRNA Protein Name
NM_133407.1 NP_596898.1 mitogen-activated protein kinase kinase kinase kinase 3

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables SH3 domain binding IPI
IPI: Inferred from physical interaction
11384986 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Map4k3 Protein Structure

STKc_MAP4K3_like

STKc_MAP4K3_like: cd06613 (14 - 272)

CNH

CNH: smart00036 (582 - 925)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 946 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase kinase kinase kinase 3

  • GLK

  • MAPK/ERK kinase kinase kinase 3

  • MEK kinase kinase 3

  • MEKKK 3

  • germinal center kinase-related protein kinase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-148065 FMF-06-098-1 Inhibitor 98.77% Unkown
HY-148061 DB1113 99.86% Unkown
HY-148063 DB0614 96.07% Unkown
HY-RS08077 MAP4K3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08078 Map4k3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08079 Map4k3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Map4k3 NCBI NCBI:8491