Gchfr - GTP cyclohydrolase I feedback regulator Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 171128

Summary

Enables several functions, including GTP cyclohydrolase binding activity; GTP-dependent protein binding activity; and amino acid binding activity. Involved in negative regulation of GTP cyclohydrolase I activity and protein-containing complex assembly. Part of protein-containing complex. Orthologous to human GCHFR (GTP cyclohydrolase I feedback regulator). [provided by Alliance of Genome Resources, Apr 2022]

Gchfr Products (1)

mRNA Protein Name
NM_133595.2 NP_598279.1 GTP cyclohydrolase 1 feedback regulatory protein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTP cyclohydrolase I regulator activity IDA
IDA: Inferred from direct assay
8702680 RGD
enables GTP cyclohydrolase binding IDA
IDA: Inferred from direct assay
8702680 RGD
enables GTP cyclohydrolase binding IPI
IPI: Inferred from physical interaction
9685352 RGD
enables GTP-dependent protein binding IPI
IPI: Inferred from physical interaction
9685352 RGD
enables amino acid binding IDA
IDA: Inferred from direct assay
11818540 RGD
enables identical protein binding IDA
IDA: Inferred from direct assay
11580249 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
11818540 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
9685352 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
15448133 RGD
Biological Process GO Annotation Evidence References Source
involved in protein-containing complex assembly IDA
IDA: Inferred from direct assay
9685352 RGD
Cellular Component GO Annotation Evidence References Source
part of intracellular protein-containing complex IDA
IDA: Inferred from direct assay
8702680 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
11818540 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

GTP cyclohydrolase 1 feedback regulatory protein

  • GFRP

  • GTP cyclohydrolase I feedback regulatory protein

  • p35

Gchfr Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Gchfr P70552 Gch1 Rattus norvegicus P22288
X-Ray Diffraction
11818540
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05328 GCHFR Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gchfr NCBI NCBI:2644