Gch1 - GTP cyclohydrolase 1 Gene

Also Known as Gch

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 29244

Summary

Enables several functions, including GTP binding activity; GTP cyclohydrolase I activity; and metal ion binding activity. Involved in several processes, including dihydrobiopterin metabolic process; response to pain; and vasodilation. Part of protein-containing complex. Human ortholog(s) of this gene implicated in BH4-deficient hyperphenylalaninemia B; bipolar disorder; dystonia; and dystonia 5. Orthologous to human GCH1 (GTP cyclohydrolase 1). [provided by Alliance of Genome Resources, Apr 2022]

Gch1 Products (1)

mRNA	Protein	Name
NM_024356.1	NP_077332.1	GTP cyclohydrolase 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables GTP binding	IDA IDA: Inferred from direct assay	2557335	RGD
enables GTP cyclohydrolase I activity	IDA IDA: Inferred from direct assay	2557335	RGD
enables GTP-dependent protein binding	IPI IPI: Inferred from physical interaction	9685352	RGD
enables calcium ion binding	IDA IDA: Inferred from direct assay	9636709	RGD
enables identical protein binding	IDA IDA: Inferred from direct assay	2557335	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	7802677	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	9685352	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	15448133	RGD
enables zinc ion binding	IDA IDA: Inferred from direct assay	11818540	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in dihydrobiopterin metabolic process	IDA IDA: Inferred from direct assay	2557335	RGD
involved in negative regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	12855421	RGD
involved in negative regulation of cardiac muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	30690003	RGD
involved in negative regulation of cellular senescence	IMP IMP: Inferred from mutant phenotype	30690003	RGD
involved in positive regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	31210282	RGD
involved in positive regulation of telomere maintenance via telomerase	IMP IMP: Inferred from mutant phenotype	30690003	RGD
involved in protein-containing complex assembly	IDA IDA: Inferred from direct assay	9685352	RGD
involved in response to pain	IDA IDA: Inferred from direct assay	17057711	RGD
involved in vasodilation	IMP IMP: Inferred from mutant phenotype	12855421	RGD

Cellular Component GO Annotation	Evidence	References	Source
part of intracellular protein-containing complex	IDA IDA: Inferred from direct assay	8702680	RGD
located in mitochondrion	IDA IDA: Inferred from direct assay	22479495	RGD
located in nucleus	IDA IDA: Inferred from direct assay	18061195	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	11818540	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
GTP cyclohydrolase 1	GTP cyclohydrase I GTP cyclohydrolase I GTP-CH-I

Gch1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Gch1	P22288	Gchfr	Rattus norvegicus	P70552	X-Ray Diffraction	11818540
Intra	Gch1	P22288	Gchfr	Rattus norvegicus	P70552	X-Ray Diffraction	15448133

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-171894	AXSP0056BS		/	Unkown
HY-RS05327	GCH1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18133	Gch1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24608	Gch1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gch1	NCBI	NCBI:2643