Slc12a5 - solute carrier family 12 member 5 Gene

Also Known as Kcc2

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 171373

Summary

Enables ammonium transmembrane transporter activity and potassium:chloride symporter activity. Involved in several processes, including cation transport; dendritic spine development; and intracellular pH reduction. Located in dendrite membrane and perikaryon. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 34 and idiopathic generalized epilepsy 14. Orthologous to human SLC12A5 (solute carrier family 12 member 5). [provided by Alliance of Genome Resources, Apr 2022]

Slc12a5 Products (2)

mRNA	Protein	Name
NM_001393675.1	NP_001380604.1	solute carrier family 12 member 5 isoform 1
NM_134363.2	NP_599190.1	solute carrier family 12 member 5 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ammonium channel activity	IDA IDA: Inferred from direct assay	15175220	RGD
enables potassium:chloride symporter activity	IDA IDA: Inferred from direct assay	9374636	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	15094054	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in ammonium transmembrane transport	IDA IDA: Inferred from direct assay	15175220	RGD
involved in chloride transport	IDA IDA: Inferred from direct assay	9374636	RGD
involved in dendritic spine development	IDA IDA: Inferred from direct assay	22345354	RGD
involved in intracellular pH reduction	IDA IDA: Inferred from direct assay	16420452	RGD
involved in postsynaptic neurotransmitter receptor diffusion trapping	IDA IDA: Inferred from direct assay	21878564	RGD
involved in postsynaptic neurotransmitter receptor diffusion trapping	IMP IMP: Inferred from mutant phenotype	21878564	RGD
involved in potassium ion transmembrane transport	IDA IDA: Inferred from direct assay	11551954	RGD
involved in potassium ion transport	IDA IDA: Inferred from direct assay	9374636	RGD
involved in regulation of postsynapse assembly	IDA IDA: Inferred from direct assay	18093524	RGD
involved in regulation of postsynapse assembly	IMP IMP: Inferred from mutant phenotype	18093524	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in dendrite membrane	IDA IDA: Inferred from direct assay	12967985	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	21878564	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	21878564	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	12967985	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
solute carrier family 12 member 5	K-Cl cotransporter 2 electroneutral potassium-chloride cotransporter 2 furosemide-sensitive K-Cl cotransporter neuronal K-Cl cotransporter neuronal-specific K-Cl cotransporter solute carrier family 12 (potassium-chloride transporter), member 5

Slc12a5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	Slc12a5	Q63633	Mycbp2	Mus musculus	Q7TPH6	Anti Bait CoIP	18769030
Cross	Slc12a5	Q63633	Mycbp2	Mus musculus	Q7TPH6	Y2H	18769030

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-160082	KCC2 Modulator-2	Modulator	/	Unkown
HY-RS13000	SLC12A5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc12a5	NCBI	NCBI:57468