Mycbp2 - MYC binding protein 2, E3 ubiquitin protein ligase Gene

Also Known as Pam; Phr1; C130061D10Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 105689

Summary

Enables identical protein binding activity. Involved in several processes, including central nervous system projection neuron axonogenesis; circadian regulation of gene expression; and positive regulation of protein ubiquitination. Acts upstream of or within several processes, including branchiomotor neuron axon guidance; negative regulation of protein catabolic process; and regulation of Cytoskeleton organization. Located in axon and microtubule Cytoskeleton. Is expressed in nervous system and neural retina. Orthologous to human MYCBP2 (MYC binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Mycbp2 Products (1)

mRNA Protein Name
NM_207215.2 NP_997098.2 E3 ubiquitin-protein ligase MYCBP2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12522145 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within branchiomotor neuron axon guidance IMP
IMP: Inferred from mutant phenotype
18031680 MGI
acts upstream of or within cell morphogenesis involved in neuron differentiation IMP
IMP: Inferred from mutant phenotype
18031680 MGI
acts upstream of or within central nervous system projection neuron axonogenesis IMP
IMP: Inferred from mutant phenotype
18031680 MGI
involved in central nervous system projection neuron axonogenesis IMP
IMP: Inferred from mutant phenotype
17901218 MGI
involved in circadian regulation of gene expression IMP
IMP: Inferred from mutant phenotype
20534529 MGI
acts upstream of or within motor neuron axon guidance IMP
IMP: Inferred from mutant phenotype
18031680 MGI
acts upstream of or within negative regulation of protein catabolic process IDA
IDA: Inferred from direct assay
19398581 MGI
involved in neuromuscular process IMP
IMP: Inferred from mutant phenotype
17901218 MGI
involved in positive regulation of protein ubiquitination IDA
IDA: Inferred from direct assay
20534529 MGI
involved in regulation of axon guidance IMP
IMP: Inferred from mutant phenotype
17901218 MGI
acts upstream of or within regulation of cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
18031680 MGI
acts upstream of or within regulation of protein localization IMP
IMP: Inferred from mutant phenotype
18031680 MGI
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
18031680 MGI
located in microtubule cytoskeleton IDA
IDA: Inferred from direct assay
18031680 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase MYCBP2

  • Myc-binding protein 2

  • RING-type E3 ubiquitin transferase MYCBP2

  • pam, highwire, rpm 1

  • pam/highwire/rpm-1 protein

  • probable E3 ubiquitin-protein ligase MYCBP2

  • protein Magellan

  • protein associated with Myc

Mycbp2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Mycbp2 Q7TPH6 Slc12a5 Rattus norvegicus Q63633
Pull Down
18769030
Cross: Cross-species interaction Intra: Intraspecies interaction

Orthologs Information

Species Symbol Source ID
Homo sapiens Mycbp2 NCBI NCBI:23077