MYCBP2 - MYC binding protein 2 Gene

Also Known as PAM; Phr; PHR1; Myc-bp2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23077

About MYCBP2

Cytogenetic location: 13q22.3 Genomic coordinates (GRCh38): 13:77,044,657-77,327,094 (from NCBI)

This gene has 29 transcripts (splice variants), 223 orthologues and 1 paralogue. Ubiquitous expression in skin (RPKM 12.3), brain (RPKM 10.8) and 25 other tissues.

Summary

This gene encodes an E3 ubiquitin-protein Ligase and member of the PHR (Phr1/MYCBP2, highwire and RPM-1) family of proteins. The encoded protein plays a role in axon guidance and synapse formation in the developing nervous system. In mammalian cells, this protein regulates the cAMP and mTOR signaling pathways, and may additionally regulate Autophagy. Reduced expression of this gene has been observed in acute lymphoblastic leukemia patients and a mutation in this gene has been identified in patients with a rare inherited vision defect. [provided by RefSeq, Mar 2017]

MYCBP2 Products (1)

mRNA Protein Name
NM_015057.5 NP_055872.4 E3 ubiquitin-protein ligase MYCBP2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables guanyl-nucleotide exchange factor activity IDA
IDA: Inferred from direct assay
26304119 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15161933 GOA
enables small GTPase binding IDA
IDA: Inferred from direct assay
26304119 GOA
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
29643511 GOA
enables zinc ion binding IDA
IDA: Inferred from direct assay
29643511 GOA
Biological Process GO Annotation Evidence References Source
involved in circadian regulation of gene expression IMP
IMP: Inferred from mutant phenotype
20534529 GOA
involved in positive regulation of protein ubiquitination IDA
IDA: Inferred from direct assay
20534529 GOA
involved in protein K48-linked ubiquitination IDA
IDA: Inferred from direct assay
29997255 GOA
involved in protein ubiquitination IDA
IDA: Inferred from direct assay
29643511 GOA
involved in protein ubiquitination IMP
IMP: Inferred from mutant phenotype
27278822 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
26304119 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MYCBP2 Protein Structure

RCC1_2

RCC1_2: Regulator of chromosome condensation (RCC1) repeat (645 - 674)

RCC1

RCC1: Regulator of chromosome condensation (RCC1) repeat (920 - 968)

PHR

PHR: PHR domain (1197 - 1347)

PHR

PHR: PHR domain (1688 - 1846)

Filamin

Filamin: Filamin/ABP280 repeat (2239 - 2396)

SH3_3

SH3_3: Bacterial SH3 domain (2440 - 2499)

zf-RING_2

zf-RING_2: Ring finger domain (4389 - 4441)

  • 0
  • 800
  • 1600
  • 2400
  • 3200
  • 4000
  • 4640 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase MYCBP2

  • Highwire

MYCBP2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MYCBP2 O75592 YWHAZ Homo sapiens P63104
Pull Down
15161933
Cross
MYCBP2 O75592 Rae1 Rattus norvegicus Q3SWS8
Anti Tag CoIP
22357847
Cross
MYCBP2 O75592 Q99IB8-PRO_0000045603 Hepatitis C virus Q99IB8-PRO_0000045603
Pull Down
24136289
Cross
MYCBP2 O75592 Q99IB8-PRO_0000045603 Hepatitis C virus Q99IB8-PRO_0000045603
Y2H
24136289
Cross: Cross-species interaction Intra: Intraspecies interaction

MYCBP2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P86968 MYCBP2 Antibody (YA6661) WB, ICC/IF, IHC-P, FC Human, Mouse, Rat

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08881 MYCBP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21160 Mycbp2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27676 Mycbp2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta MYCBP2 VGNC VGNC:75011
Canis familiaris MYCBP2 VGNC VGNC:43528
Bos taurus MYCBP2 VGNC VGNC:31785
Felis catus MYCBP2 VGNC VGNC:63670
Rattus norvegicus MYCBP2 RGD RGD:1312048
Mus musculus MYCBP2 MGD MGI:2179432
Others MYCBP2 NCBI