NLRP6 - NLR family pyrin domain containing 6 Gene

Homo sapiens

Also known as AVR; NAVR; PAN3; NALP6; PYPAF5; CLR11.4; NAVR/AVR

Gene ID: 171389 | Gene type: protein coding

About NLRP6

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:278,407-285,388 (from NCBI)

This gene has 3 transcripts (splice variants), 67 orthologues and 20 paralogues. Biased expression in duodenum (RPKM 17.8), small intestine (RPKM 17.7) and 3 other tissues.

Summary

The protein encoded by this gene binds arginine-vasopressin and may be involved in the arginine-vasopressin-mediated regulation of renal salt-water balance. The encoded protein also mediates inflammatory responses in the colon to allow recovery from intestinal epithelial damage and protects against tumorigenesis and the development of colitis. Finally, this protein can increase activation of NF-kappa-B, activation of CASP1 through interaction with ASC, and cAMP accumulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]

NLRP6 Products(2)

mRNA	Protein	Name
NM_001276700.2	NP_001263629.1	NACHT, LRR and PYD domains-containing protein 6 isoform 2
NM_138329.2	NP_612202.2	NACHT, LRR and PYD domains-containing protein 6 isoform 1

NLRP6 Protein Structure

PYRIN

NACHT

0
200
400
600
800
892 a.a.

Protein Preferred Names

Protein Names

NACHT, LRR and PYD domains-containing protein 6

NACHT, leucine rich repeat and PYD containing 6

Related Diseases

Diseases

Alias

Chemical Colitis

Familial Cold Autoinflammatory Syndrome

Familial Cold Urticaria	Fcas
Familial Polymorphous Cold Eruption	Fcu
Cold Hypersensitivity

Cinca Syndrome

CINCA	Nomid
Cryopyrin-Associated Periodic Syndrome 3	Chronic Neurologic Cutaneous And Articular Syndrome
Multisystem Inflammatory Disease, Neonatal-Onset	Caps3
Chronic Infantile Neurological Cutaneous Articular Syndrome	Infantile-Onset Multisystem Inflammatory Disease
Iomid Syndrome	Neonatal-Onset Multisystem Inflammatory Disease
Nomid Syndrome	Prieur-Griscelli Syndrome
Neonatal Onset Multisystem Inflammatory Disease	Chronic Infantile Neurological, Cutaneous And Articular Syndrome
Iomid	Infantile Onset Multisystem Inflammatory Disease
Prieur Griscelli Syndrome	Chronic Infantile Neurological Cutaneous And Articular Syndrome
Chronic, Infantile, Neurological, Cutaneous, Articular Syndrome	Chronic Infantile Neurologic Cutaneous And Articular Syndrome
Chronic Infantile Neurological, Cutaneous, And Articular Syndrome	Cryopyrin-Associated Periodic Syndromes

Salmonellosis

Salmonella Infections

Salmonella Infection

Colonic Benign Neoplasm

Colon Neoplasm	Colonic Mass
Colonic Tumor	Neoplasm Of Colon
Neoplasm Of The Colon	Colonic Neoplasms
Colon Cancer	Colon Carcinoma Nos
Colonic Cancer	Metastatic Colon Cancer Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09362	NLRP6 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	NLRP6	VGNC	VGNC:75234
Mus musculus	NLRP6	MGD	MGI:2141990
Rattus norvegicus	NLRP6	RGD	RGD:708549
Bos taurus	NLRP6	VGNC	VGNC:32119
Canis familiaris	NLRP6	VGNC	VGNC:43850
Felis catus	NLRP6	VGNC	VGNC:81969
Others	NLRP6	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.