Mc2r - melanocortin 2 receptor Gene

Also Known as ACTHR; MC2-R; ACTH-R

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17200

About Mc2r

Chromosome 18: 68,539,978-68,562,391 reverse strand.GRCm39:CM001011.3

This gene has 1 transcript (splice variant), 178 orthologues, 18 paralogues and is associated with 24 phenotypes. Biased expression in adrenal adult (RPKM 74.8) and subcutaneous fat pad adult (RPKM 7.1).

Summary

Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and regulation of metabolic process. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including adrenal gland; brain; hemolymphoid system gland; lung; and reproductive system. Human ortholog(s) of this gene implicated in West syndrome and glucocorticoid deficiency 1. Orthologous to human MC2R (melanocortin 2 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Mc2r Products (4)

mRNA Protein Name
NM_001271716.1 NP_001258645.1 adrenocorticotropic hormone receptor
NM_001301372.1 NP_001288301.1 adrenocorticotropic hormone receptor
NM_008560.3 NP_032586.1 adrenocorticotropic hormone receptor
NM_001271717.1 NP_001258646.1 adrenocorticotropic hormone receptor

Mc2r Protein Structure

7tmA_MC2R_ACTH_R

7tmA_MC2R_ACTH_R: cd15350 (24 - 286)

7tmA_MC2R_ACTH_R

7tmA_MC2R_ACTH_R: cd15350 (25 - 51)

7tmA_MC2R_ACTH_R

7tmA_MC2R_ACTH_R: cd15350 (58 - 84)

7tmA_MC2R_ACTH_R

7tmA_MC2R_ACTH_R: cd15350 (102 - 132)

7tmA_MC2R_ACTH_R

7tmA_MC2R_ACTH_R: cd15350 (144 - 164)

7tmA_MC2R_ACTH_R

7tmA_MC2R_ACTH_R: cd15350 (169 - 198)

7tmA_MC2R_ACTH_R

7tmA_MC2R_ACTH_R: cd15350 (211 - 241)

7tmA_MC2R_ACTH_R

7tmA_MC2R_ACTH_R: cd15350 (254 - 279)

  • 0
  • 100
  • 200
  • 296 a.a.
Protein Preferred Names Protein Names

adrenocorticotropic hormone receptor

  • ACTH receptor

  • adrenocorticotropin receptor

  • melanocortin receptor 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P1477 Adrenocorticotropic hormone (1-39), rat Agonist 99.31% Unkown
HY-P1477A Adrenocorticotropic hormone (1-39), rat TFA Agonist 99.84% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mc2r NCBI NCBI:4158